炔诺酮联合黄体酮治疗围绝经期异常子宫出血患者的效果  

Effects of Norethisterone combined with Progesterone in treatment of patients with perimenopausal abnormal uterine bleeding

作　　者：刘勤勤 LIU Qinqin(Department of Obstetrics and Gynecology of Henan No.3 Provincial People’s Hospital,Zhengzhou 450000 Henan,China)

机构地区：[1]河南省直第三人民医院妇产科,河南郑州450000

出　　处：《中国民康医学》2024年第23期53-55,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察炔诺酮联合黄体酮治疗围绝经期异常子宫出血(AUB)患者的效果。方法:选取2020年8月至2023年8月该院收治的86例围绝经期AUB患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各43例。对照组给予黄体酮治疗,观察组在对照组基础上联合炔诺酮治疗,比较两组临床疗效,治疗前后性激素[卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_(2))]水平、子宫内膜厚度、月经量[月经失血图(PBAC)]评分,以及不良反应发生率。结果:观察组治疗总有效率为95.35%(41/43),高于对照组的79.07%(34/43),差异有统计学意义(P<0.05);治疗后,两组FSH、LH、E_(2)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组子宫内膜厚度、PBAC评分均低于治疗前,且观察低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:炔诺酮联合黄体酮治疗围绝经期AUB患者可提高治疗总有效率,以及降低性激素水平、子宫内膜厚度和PBAC评分的效果优于单纯黄体酮治疗。Objective:To observe effects of Norethisterone combined with Progesterone in treatment of patients with perimenopausal abnormal uterine bleeding(AUB).Methods:A prospective study was conducted on 86 patients with perimenopausal AUB admitted to the hospital from August 2020 to August 2023.According to the random number table method,they were divided into control group and observation group,43 cases in each group.The control group was treated with Progesterone,while the observation group was treated with Norethisterone on the basis of that of the control group.The clinical efficacy,the sex hormone[follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2))]levels,the endometrial thickness,and the menstrual volume[pictorial blood loss assessment chart(PBAC)]score before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.35%(41/43),which was higher than 79.07%(34/43)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FSH,LH,E_(2) and other sex hormone indexes in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the endometrial thickness levels and the PBAC scores of the two groups were lower than those before the treatment,those in the observation were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Norethisterone combined with Progesterone in the treatment of the perimenopausal AUB patients can improve the total effective rate of treatment,and reduce the levels of sex hormone,the endometrial thickness and the PBAC scores.Moreover,it is superior to simple Progesterone treatment.

关 键 词：异常子宫出血 围绝经期 黄体酮 炔诺酮 性激素 子宫内膜厚度 不良反应 

分 类 号：R711.52[医药卫生—妇产科学]