血清PCT、IL-6、ET-1水平联合检测在重症肺炎继发呼吸衰竭诊断中的效能  

Efficiency of combined detection of serum PCT,IL-6 and ET-1 levels in diagnosis of respiratory failure secondary to severe pneumonia

作　　者：西俊英 XI Junying(Emergency Department of Kaifeng People’s Hospital,Kaifeng 475000 Henan,China)

机构地区：[1]开封市人民医院急诊科,河南开封475000

出　　处：《中国民康医学》2024年第23期107-109,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清降钙素原(PCT)、白细胞介素-6(IL-6)、内皮素-1(ET-1)水平联合检测在重症肺炎继发呼吸衰竭诊断中的效能。方法:选取2020年5月至2023年8月该院收治的126例重症肺炎患者为研究组,另选取同期该院126名健康体检者为对照组。比较两组、继发呼吸衰竭与未继发呼吸衰竭患者血清PCT、IL-6、ET-1水平,绘制受试者工作特征曲线(ROC),计算曲线下面积(AUC),分析血清PCT、IL-6、ET-1水平单项及联合检测在重症肺炎继发呼吸衰竭诊断中的效能。结果:研究组血清PCT、IL-6、ET-1水平均高于对照组,差异有统计学意义(P<0.05);继发呼吸衰竭患者血清PCT、IL-6、ET-1水平均高于未继发呼吸衰竭患者,差异有统计学意义(P<0.05);ROC曲线分析结果显示,血清PCT、IL-6、ET-1水平单项及联合检测诊断重症肺炎继发呼吸衰竭的AUC分别为0.706、0.659、0.668、0.887,且联合检测高于各单项检测。结论:血清PCT、IL-6、ET-1水平联合检测诊断重症肺炎继发呼吸衰竭的效能高于各单项检测。Objective:To analyze efficiency of combined detection of serum procalcitonin(PCT),interleukin-6(IL-6)and endothelin-1(ET-1)levels in diagnosis of respiratory failure secondary to severe pneumonia.Methods:126 patients with severe pneumonia admitted to the hospital from May 2020 to August 2023 were selected as the study group,and 126 healthy subjects in the hospital during the same period were selected as the control group.The levels of serum PCT,IL-6 and ET-1 were compared between the two groups and among the patients with secondary respiratory failure and without secondary respiratory failure.The receiver operating characteristic curve(ROC)was drawn,and the area under the curve(AUC)was calculated.The efficiencies of single and combined detection of serum PCT,IL-6 and ET-1 levels in the diagnosis of respiratory failure secondary to severe pneumonia were analyzed.Results:The levels of serum PCT,IL-6 and ET-1 in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of serum PCT,IL-6 and ET-1 in the patients with secondary respiratory failure were higher than those in the patients without secondary respiratory failure,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the AUCs of single and combined detection of serum PCT,IL-6 and ET-1 levels in the diagnosis of respiratory failure secondary to severe pneumonia were 0.706,0.659,0.668 and 0.887,separately;the efficiency of the combined detection was higher than that of each single detection.Conclusions:The efficiency of combined detection of serum PCT,IL-6 and ET-1 levels in the diagnosis of respiratory failure secondary to severe pneumonia is higher than that of each single detection.

关 键 词：重症肺炎 呼吸衰竭 降钙素原 白细胞介素-6 内皮素-1 诊断 

分 类 号：R563.8[医药卫生—呼吸系统]