血清Adropin、TLR4、GMP-140水平与不稳定型心绞痛患者冠状动脉病变程度的相关性  

Analysis of correlations among serum Adropin,TLR4,GMP-140 levels and severity of coronary artery disease in patients with unstable angina pectoris

作　　者：田新 TIAN Xin(Department of Internal Medicine of Shangqiu Fifth People’s Hospital,Shangqiu 476000 Henan,China)

机构地区：[1]商丘市第五人民医院内科,河南商丘476000

出　　处：《中国民康医学》2024年第23期122-124,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清能量平衡相关蛋白(Adropin)、Toll样受体4(TLR4)、血小板颗粒膜蛋白140(GMP-140)水平与不稳定型心绞痛患者冠状动脉病变程度的相关性。方法:回顾性分析2021—2023年该院收治的107例不稳定型心绞痛患者的临床资料,设为研究组,另选取同期107名健康体检者作为对照组。比较两组及不同冠状动脉病变程度、病变血管数不稳定型心绞痛患者血清Adropin、TLR4、GMP-140水平,采用Spearman相关性分析Adropin、TLR4、GMP-140水平与冠状动脉病变程度的相关性。结果:研究组血清Adropin水平低于对照组,TLR4、GMP-140水平均高于对照组,差异有统计学意义(P<0.05);重度病变患者血清Adropin水平低于轻中度病变患者,TLR4、GMP-140水平均高于轻中度病变患者,差异有统计学意义(P<0.05);不同冠状动脉病变血管数患者血清Adropin水平比较:三支病变患者<双支病变患者<单支病变患者;不同冠状动脉病变血管数患者TLR4、GMP-140水平比较:三支病变患者>双支病变患者>单支病变患者,差异均有统计学意义(P<0.05);经Spearman相关性分析结果显示,血清Adropin水平与冠状动脉病变程度、病变血管数均呈负相关(r<0,P<0.05);血清TLR4、GMP-140水平与冠状动脉病变程度、病变血管数均呈正相关(r>0,P<0.05)。结论:血清Adropin、TLR4、GMP-140水平与不稳定型心绞痛患者冠脉病变程度存在相关性。Objective:To analyze correlations between among serum Adropin,Toll-like receptor 4(TLR4),platelet granule membrane protein 140(GMP-140)levels and severity of coronary artery disease in patients with unstable angina pectoris.Methods:The clinical data of 107 patients with unstable angina pectoris admitted to this hospital from 2021 to 2023 were retrospectively analyzed and they were set as the study group;another 107 healthy subjects were selected as the control group.The serum levels of Adropin,TLR4 and GMP-140 were compared between the two groups and among the unstable angina pectoris patients with different severities of coronary artery disease and numbers of diseased vessels.Spearman correlation analysis was used to analyze the correlations among the Adropin,TLR4,GMP-140 levels and the severity of coronary artery disease.Results:The serum Adropin level of the study group was lower than that of the control group,the levels of TLR4 and GMP-140 were higher than those of the control group,and the differences were statistically significant(P<0.05).The serum Adropin level in the patients with severe disease was lower than that in the patients with mild to moderate disease,the levels of TLR4 and GMP-140 were higher than those in the patients with mild to moderate disease,and the differences were statistically significant(P<0.05).The comparison of the serum Adropin levels in the patients with numbers of diseased vessels showed that:the patients with three-vessel disease<the patients with double-vessel disease<the patients with single-vessel disease;the comparison of TLR4 and GMP-140 levels in the patients with numbers of diseased vessels showed that:the patients with three-vessel disease>the patients with double-vessel disease>the patients with single-vessel disease;and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that serum Adropin level was negatively correlated with the severity of coronary artery disease and the number of diseased vessels(r<0,P<0.05);and the serum TLR4

关 键 词：不稳定型心绞痛 能量平衡相关蛋白 TOLL样受体4 血小板颗粒膜蛋白140 病变程度 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]