血清25-(OH)D_(3)、BMP-7、S100A8水平与新生儿呼吸窘迫综合征患儿预后不良的相关性  

Correlations between serum 25-(OH)D3,BMP-7,S100A8 levels and poor prognosis in children with neonatal respiratory distress syndrome

作　　者：何莉霞 HE Lixia(Department of Neonatology of Shangcai County People’s Hospital,Zhumadian 463800 Henan,China)

机构地区：[1]上蔡县人民医院新生儿科,河南驻马店463800

出　　处：《中国民康医学》2024年第23期128-130,134,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清25羟基维生素D_(3)[25-(OH)D_(3)]、骨形态发生蛋白-7(BMP-7)、S100钙结合蛋白A8(S100A8)水平与新生儿呼吸窘迫综合征患儿预后不良的相关性。方法:选取2021年4月至2023年7月该院收治的117例新生儿呼吸窘迫综合征患儿为研究组,另选取同期该院117名健康新生儿为对照组。比较两组及不同病情严重程度分级、不同预后患儿血清25-(OH)D_(3)、BMP-7、S100A8水平,采用Spearman相关性分析血清25-(OH)D_(3)、BMP-7、S100A8水平与新生儿呼吸窘迫综合征患儿预后不良的相关性。结果:研究组血清25-(OH)D_(3)水平低于对照组,血清BMP-7、S100A8水平高于对照组,差异均有统计学意义(P<0.05);Ⅳ级患儿血清25-(OH)D_(3)水平低于Ⅲ、Ⅱ、Ⅰ级患儿,且病情严重程度分级越高,血清25-(OH)D_(3)水平越低,Ⅳ级患儿血清BMP-7、S100A8水平高于Ⅲ、Ⅱ、Ⅰ级患儿,且病情严重程度分级越高,血清BMP-7、S100A8水平越高,差异均有统计学意义(P<0.05);预后不良患儿血清25-(OH)D_(3)水平低于预后良好患儿,血清BMP-7、S100A8水平高于预后良好患儿,差异均有统计学意义(P<0.05);血清25-(OH)D_(3)水平与新生儿呼吸窘迫综合征患儿预后不良呈负相关(r<0,P<0.05),血清BMP-7、S100A8水平与新生儿呼吸窘迫综合征患儿预后不良均呈正相关(r>0,P<0.05)。结论:血清25-(OH)D_(3)水平与新生儿呼吸窘迫综合征患儿预后不良呈负相关,血清BMP-7、S100A8水平与新生儿呼吸窘迫综合征患儿预后不良均呈正相关。Objective:To analyze correlations between serum 25-hydroxyvitamin D3[25-(OH)D3],bone morphogenetic protein-7(BMP-7),S100 calcium binding protein A8(S100A8)levels and poor prognosis in children with neonatal respiratory distress syndrome.Methods:A total of 117 children with neonatal respiratory distress syndrome admitted to this hospital from April 2021 to July 2023 were selected as the study group,and 117 healthy newborns during the same period were selected as the control group.The levels of serum 25-(OH)D3,BMP-7 and S100 A8 were compared between the two groups as well as the children with different severity grades and different prognosis.Spearman correlation analysis was used to analyze the correlations between the serum 25-(OH)D3,BMP-7,S100A8 levels and poor prognosis in the children with neonatal respiratory distress syndrome.Results:The level of serum 25-(OH)D3 in the study group was lower than that in the control group,the levels of serum BMP-7 and S100A8 were higher than those in the control group,and the differences were statistically significant(P<0.05).The serum 25-(OH)D3 level of the children with grade IV was lower than those of the children with grade III,II and I,and the higher the severity of the disease was,the lower the serum 25-(OH)D3 level was;the levels of serum BMP-7 and S100 A8 in the children with grade IV were higher than those in the children with grade III,II and I,and the higher the severity of the disease was,the higher the levels of serum BMP-7 and S100 A8 were;and the differences were statistically significant(P<0.05).The level of serum 25-(OH)D3 in the children with poor prognosis was lower than that in the children with good prognosis,the levels of serum BMP-7 and S100 A8 were higher than those in the children with good prognosis,and the differences were statistically significant(P<0.05).The serum 25-(OH)D3 level was negatively correlated with poor prognosis in the children with neonatal respiratory distress syndrome(r<0,P<0.05),while the serum BMP-7 and S100 A8 levels were positiv

关 键 词：25羟基维生素D_(3) 骨形态发生蛋白-7 S100钙结合蛋白A8 新生儿呼吸窘迫综合征 预后不良 相关性 

分 类 号：R725.6[医药卫生—儿科]