德谷门冬双胰岛素与基础-餐时胰岛素短期强化治疗2型糖尿病患者的效果比较  

Comparison of effects of short-term intensive insulin therapy with Insulin degludec and Insulin aspart and basal-prandial insulin in patients with type 2 diabetes mellitus

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作  者:秦小静 QIN Xiaojing(Department of Endocrine Nephrology of Qinyang People’s Hospital,Jiaozuo 454550 Henan,China)

机构地区:[1]沁阳市人民医院内分泌肾病科,河南焦作454550

出  处:《中国民康医学》2024年第23期135-138,共4页Medical Journal of Chinese People’s Health

摘  要:目的:比较德谷门冬双胰岛素与基础-餐时胰岛素短期强化治疗2型糖尿病患者的效果。方法:回顾性分析2021年1月至2023年10月该院收治的80例2型糖尿病患者的临床资料,按照治疗方法不同将其分为观察组与对照组各40例。对照组采用基础-餐时胰岛素短期强化治疗,观察组采用德谷门冬双胰岛素治疗。比较两组治疗前后血糖指标[空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)]水平、胰岛β细胞功能[胰岛β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)]、血清成纤维细胞生长因子-23(FGF-23)、颗粒蛋白前体(PGRN)水平,以及不良反应发生率。结果:治疗后,两组FPG、HbA1c、2hPG水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组HOMA-β水平高于治疗前,且观察组高于对照组,两组HOMA-IR水平低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05);治疗后,两组FGF-23、PGRN水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为5.00%(2/40),低于对照组的22.50%(9/40),差异有统计学意义(P<0.05)。结论:德谷门冬双胰岛素治疗2型糖尿病患者可改善胰岛β细胞功能,降低血糖水平及不良反应发生率,减轻胰岛素抵抗,效果优于基础-餐时胰岛素短期强化治疗。Objective:To compare effects of short-term intensive treatment of type 2 diabetes mellitus with Insulin degludec and Insulin aspart and basal-prandial insulin.Methods:The clinical data of 80 patients with type 2 diabetes mellitus admitted to this hospital from January 2021 to October 2023 were retrospectively analyzed.According to different treatment methods,they were divided into observation group and control group,40 cases in each group.The control group was treated with short-term intensive insulin therapy with basal-prandial insulin,while the observation group was treated with Insulin degludec and Insulin aspart.The levels of blood glucose indexes[fasting blood glucose(FPG),2 h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c)],isletβcell function[isletβcell function index(HOMA-β),homeostasis model assessment of insulin resistance(HOMA-IR)],serum fibroblast growth factor-23(FGF-23)and progranulin(PGRN),and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the levels of FPG,HbA1c and 2hPG in the two groups were lower than those before the treatment,those in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of HOMA-βin the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the HOMA-IR levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of FGF-23 and PGRN in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was 5.00%(2/40),which was lower than 22.50%(9/40)in the control group,and the differ

关 键 词:2型糖尿病 德谷门冬双胰岛素 基础-餐时胰岛素 胰岛Β细胞功能 

分 类 号:R587.1[医药卫生—内分泌]

 

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