生脉饮合五苓散加减汤联合诺欣妥治疗心力衰竭的临床观察  

Clinical Observation of Shengmaiyin,Wuling SAN,and Noxintol for Heart Failure

作　　者：徐一慧[1] 徐冰清[1] 高艳 郭正丽[1] Xu Yihui;Xu Bingqing;Gao Yan(The First People's Hospital of Kunshan,Kunshan,Jiangsu,215300,China)

机构地区：[1]江苏大学附属昆山第一人民医院,江苏昆山215300

出　　处：《黑龙江医学》2024年第24期2995-2998,共4页Heilongjiang Medical Journal

基　　金：昆山市中医药科技发展基金项目(KZYY2222)。

摘　　要：目的:观察生脉饮合五苓散加减汤联合诺欣妥治疗心力衰竭(HF)的临床效果。方法:选取2020年10月—2021年10月江苏大学附属昆山第一人民医院收治的96例HF患者作为研究对象,采用随机数表法分为对照组和观察组,每组各48例。两组患者均给予强心、利尿、扩血管等基础治疗,对照组加用诺欣妥治疗,观察组加用生脉饮合五苓散加减汤联合诺欣妥治疗。记录两组患者临床疗效,对比治疗前后心功能变化,并分析预后不良反应发生情况。结果:治疗4周后,观察组有效治疗率显著高于对照组,差异有统计学意义(χ^(2)=4.042,P<0.05)。治疗后,观察组的左心室功能指标LVEDD、LVESD显著低于对照组,差异均有统计学意义(t=5.244、4.542,P<0.05)。在治疗期间,两组患者均未出现严重不良反应,恶心呕吐、头晕乏力、腹泻、皮肤过敏等不良反应发生率,差异均无统计学意义(χ^(2)=1.043、0.344、0.340、0、0.801,P>0.05)。根据logistics回归模型分析,患者年龄和心率均为药物安全性的影响因素(OR=0.392、0.916,P<0.05)。结论:生脉饮合五苓散加减汤联合诺欣妥可显著提高HF患者整体疗效。Objective:The therapeutic impact of Shengmaiyin,Wuling SAN,and Noxintol in treating heart failure(HF).Methods:96 HF patients from October 2020 to October 2021 in the hospital were randomly divided into control group(n=48)and observation group(n=48).Both groups got cardiotonic,diuretic,vasodilator and other basic treatments.The control group received nosintol,while the observation group received Shengmaiyin,Wuling SAN and nosintol.Clinical effectiveness,heart function changes before and after therapy,and adverse prognostic responses of two groups were compared.Results:After 4 weeks of treatment,the effective treatment rate in the observation group was significantly higher than that in the control group,and the difference was statistically significant(χ^(2)=4.042,P<0.05).After treatment,the left ventricular function indexes LVEDD and LVESD in the observation group were significantly lower than those in the control group,with statistically significant difference(t=5.244,4.542;P<0.05).During the treatment period,no serious adverse reactions occurred in the two groups.The incidence of adverse reactions such as nausea and vomiting,dizziness and fatigue,diarrhea and skin allergy was not statistically significant(χ^(2)=1.043、0.344、0.340、0、0.801,P>0.05).According to the analysis of logistics regression model,both patient age and heart rate were influential factors for drug safety(OR=0.392、0.916,P<0.05).Conclusion:Shengmaiyin,Wuling SAN and Noxintol can significantly improve the overall curative effect of HF patients.

关 键 词：心力衰竭 生脉饮合五苓散加减汤 诺欣妥 心功能 

分 类 号：R259[医药卫生—中西医结合]