脑脊液生化指标联合检验对结核性脑膜炎患者的诊断效能分析  

Analysis of Diagnostic Efficacy of Combined Detection of Cerebrospinal Fluid Biochemical Indexes in Patients with Tuberculous Meningitis

作　　者：易丹 陈梅 王瑞松 YI Dan;CHEN Mei;WANG Ruisong(Department of Emergency,Guiyang Public Health Treatment Center,Guiyang 550002,Guizhou,China)

机构地区：[1]贵阳市公共卫生救治中心急诊科,贵州贵阳550002

出　　处：《系统医学》2024年第22期1-4,共4页Systems Medicine

基　　金：2023年度贵州省卫生健康委科学技术基金项目(gzwkj2023-013)。

摘　　要：目的分析结核性脑膜炎检验中采取脑脊液生化指标联合检验效能。方法非随机选取贵阳市公共卫生救治中心于2023年1月—2024年5月收治的47例经脑脊液生化检验确诊的结核性脑膜炎受检者为观察组,50名同期接受健康体检的受试者为对照组。行腰椎穿刺留取脑脊液样本进行生化检验,通过ROC曲线分析不同检验指标(腺苷脱氨酶、蛋白、葡萄糖和氯化物)的单一指标与联合指标检测的诊断价值。结果观察组脑脊液中蛋白及腺苷脱氨酶指标表达水平均高于对照组,葡萄糖、氯化物均低于对照组,差异有统计学意义(P均<0.05)。ROC曲线分析结果显示,联合指标检测的敏感度为98.48%、特异度为94.27%、曲线下面积为0.993,均高于单一指标蛋白的93.62%、91.55%、0.984,葡萄糖的44.81%、83.80%、0.628,氯化物的71.24%、58.40%、0.641及腺苷脱氨酶的80.85%、81.00%、0.851。结论脑脊液生化指标中联合指标诊断效能优于单一指标,具有较高的诊断价值。Objective To analyze the combined test efficiency of cerebrospinal fluid biochemical indexes in tuberculous meningitis test.Methods From January 2023 to May 2024,forty-seven patients with tuberculous meningitis diagnosed by cerebrospinal fluid biochemical test in Guiyang Public Health Treatment Center were non-randomly selected as the observation group,and fifty subjects who received physical examination during the same period were selected as the control group.The cerebrospinal fluid samples were collected by lumbar puncture for biochemical test.The diagnostic value of single index and combined index detection of different test indexes(adenosine deaminase,protein,glucose and chloride)was analyzed by ROC curve.Results The expression levels of protein and adenosine deaminase in cerebrospinal fluid in the observation group were higher than those in the control group,and the levels of glucose and chloride were lower than those in the control group,the differences were statistically significant(all P<0.05).The results of ROC curve analysis showed that the sensitivity,specificity and area under the curve of combined index detection were 98.48%,94.27%and 0.993,respectively,which were higher than those of single index protein(93.62%,91.55%,0.984),glucose(44.81%,83.80%,0.628),chloride(71.24%,58.40%,0.641)and adenosine deaminase(80.85%,81.00%,0.851).Conclusion The diagnostic efficiency of combined indicators in cerebrospinal fluid biochemical indicators is better than that of single indicators,which has high diagnostic value.

关 键 词：结核性脑膜炎 脑脊液 检验效能 腺苷脱氨酶 氯化物 葡萄糖 

分 类 号：R4[医药卫生—临床医学]