富血小板血浆联合VSD在足部慢性创面修复中的临床应用研究  

Clinical Application of Platelet-rich Plasma Combined with VSD in the Repair of Chronic Foot Wound

作　　者：程忠勇 傅志均 梁宝娟 周丽嫦 陈演志 CHENG Zhongyong;FU Zhijun;LIANG Baojuan;ZHOU Lichang;CHEN Yanzhi(Shunde Heping Surgery Hospital,Foshan 528300,Guangdong,China)

机构地区：[1]顺德和平外科医院,广东佛山528300

出　　处：《系统医学》2024年第22期37-40,共4页Systems Medicine

基　　金：2022年佛山市自筹经费类科技创新项目项目(2220001004949)。

摘　　要：目的探究富血小板血浆联合封闭负压引流技术(vacuum sealing drainage,VSD)对足部慢性创面修复的影响。方法非随机选取2020年6月—2024年2月顺德和平外科医院收治的58例足部慢性创面患者作为研究对象。按照治疗方法的不同将患者分为联合组和VSD组,各29例。VSD组接受常规VSD治疗,联合组接受富血小板血浆联合VSD治疗。观察两组患者的治疗效果、创面愈合情况、患足感觉、足背动脉搏动情况。结果联合组的治疗有效率为93.10%(27/29),高于VSD组的72.41%(21/29),差异有统计学意义(χ^(2)=4.350,P<0.05)。联合组患者的创面愈合时间、感染控制时间、肉芽组织生长活跃时间均短于VSD组,差异有统计学意义(P均<0.05)。治疗20 d后,联合组患者的模拟视觉评分量表评分低于VSD组,差异有统计学意义(P<0.05)。联合组足背动脉最快血流速度、最慢血流速度均高于VSD组,动脉阻力指数低于VSD组,差异有统计学意义(P均<0.05)。结论富血小板血浆联合VSD可有效提高对足部慢性创面患者的治疗有效率,加速创面愈合,缓解患足疼痛,改善足背动脉血流。Objective To explore the effect of platelet-rich plasma combined with vacuum sealing drainage(VSD)on the repair of chronic foot wounds.Methods A total of fifty-eight patients with chronic foot wounds admitted to Shunde Heping Surgery Hospital from June 2020 to February 2024 were non-randomly selected as the study subjects.According to the different treatment methods,the patients were divided into combined group and VSD group,with twenty-nine cases in each group.The VSD group received conventional VSD treatment,and the combined group received platelet-rich plasma combined with VSD treatment.The therapeutic effect,wound healing,foot sensation and dorsalis pedis artery pulsation of the two groups were observed.Results The effective rate of treatment in the combined group was 93.10%(27/29),which was higher than 72.41%(21/29)in the VSD group,and the difference was statistically significant(χ^(2)=4.350,P<0.05).The wound healing time,infection control time and active growth time of granulation tissue in the combined group were shorter than those in the VSD group,and the differences were statistically significant(all P<0.05).After 20 days of treatment,the visual analogue scale score of the combined group was lower than that of the VSD group,and the difference was statistically significant(P<0.05).The fastest blood flow velocity and the slowest blood flow velocity of dorsalis pedis artery in the combined group were higher than those in the VSD group,and the arterial resistance index was lower than that in the VSD group,and the differences were statistically significant(all P<0.05).Conclusion Platelet-rich plasma combined with VSD can effectively improve the treatment efficiency of patients with chronic foot wounds,accelerate wound healing,relieve foot pain,and improve dorsal artery blood flow.

关 键 词：足部慢性创面 富血小板血浆 封闭负压引流技术 创面愈合 足背动脉搏动 

分 类 号：R632[医药卫生—外科学]