评价药物联合血液灌流治疗重度急性有机磷中毒的效果  

To Evaluate the Effect of Drugs Combined with Hemoperfusion on Severe Acute Organophosphorus Poisoning

作　　者：牛家林 何洪洋 魏巍 NIU Jialin;HE Hongyang;WEI Wei(Department of Emergency Medicine,Tengzhou Central People's Hospital,Tengzhou 277500,Shandong,China)

机构地区：[1]滕州市中心人民医院急诊内科,山东滕州277500

出　　处：《系统医学》2024年第22期105-107,119,共4页Systems Medicine

摘　　要：目的探讨重度急性有机磷中毒患者采用药物+血液灌流治疗的临床效果。方法非随机选取2022年1月—2023年5月滕州市中心人民医院收治的68例重度急性有机磷中毒患者为研究对象,按治疗方式不同分为两组,每组34例,参照组采用盐酸戊乙奎醚+血必净治疗,研究组在参照组基础上联用血液灌流治疗。比较两组的治疗效果、不良反应发生率、治疗恢复进程及心肾功能水平。结果研究组的总有效率为97.06%(33/34),高于参照组的76.47%(26/34),差异有统计学意义(χ^(2)=4.610,P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。研究组的治疗恢复进程以及心肾功能均优于参照组,差异有统计学意义(P均<0.05)。结论重度急性有机磷中毒患者联合使用药物以及血液灌流治疗,可确保安全性,同时提升疗效,有效缩短治疗恢复进程并改善心肾功能水平。Objective To investigate the clinical effect of drug plus hemoperfusion in patients with severe acute organophosphorus poisoning.Methods A total of sixty-eight patients with severe acute organophosphorus poisoning admitted to Tengzhou Central People's Hospital from January 2022 to May 2023 were non-randomly selected as the study subjects and divided into two groups according to different treatment methods,with thirty-four cases in each group.The reference group was treated with penehylequinone hydrochloride plus Xuebijing,and the study group was treated with hemoperfusion based on the reference group.The therapeutic effect,incidence of adverse reactions,recovery process and cardiac and renal function levels were compared between the two groups.Results The total effective rate of the study group was 97.06%(33/34),which was higher than 76.47%(26/34)of the reference group,and the difference was statistically significant(χ^(2)=4.610,P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).The treatment recovery process and cardiac and renal function of the study group were better than those of the reference group,and the differences were statistically significant(all P<0.05).Conclusion The combined use of drugs and hemoperfusion in patients with severe acute organophosphorus poisoning can ensure safety,improve efficacy,effectively shorten the treatment recovery process and improve the level of cardiac and renal function.

关 键 词：重度急性有机磷中毒 药物 血液灌流 疗效 不良反应 治疗恢复进程 心肾功能水平 

分 类 号：R4[医药卫生—临床医学]