冠状动脉粥样硬化性心脏病应用盐酸替罗非班治疗的效果评价  

Evaluation of the Therapeutic Effect of Tirofiban Hydrochloride on Coronary Atherosclerotic Heart Disease

作　　者：马旭 朱成振 许康世 MA Xu;ZHU Chengzhen;XU Kangshi(Department of Cardiovascular Medicine,Yancheng First People's Hospital,Yancheng 224001,Jiangsu,China)

机构地区：[1]盐城市第一人民医院心血管内科,江苏盐城224001

出　　处：《系统医学》2024年第22期108-111,共4页Systems Medicine

摘　　要：目的探究冠状动脉粥样硬化性心脏病(简称冠心病)应用盐酸替罗非班治疗的效果。方法非随机选取2021年11月—2023年11月盐城市第一人民医院收治的120例冠心病患者为研究对象,按治疗方法差异分为两组,每组60例。患者均接受冠脉介入治疗,对照组术后予常规抗凝治疗,研究组联用盐酸替罗非班,比对两组的疗效、不良反应、心功能和血管内皮功能。结果研究组的总有效率为96.67%(58/60),高于对照组的86.67%(52/60),差异有统计学意义(χ^(2)=3.927,P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。研究组的血清炎性因子水平优于对照组,心功能及血管内皮功能均优于对照组,差异有统计学意义(P均<0.05)。结论基础疗法联合盐酸替罗非班治疗冠心病的总体效果优异,可缓解胸部窒息感和胸痛程度,降低机体炎症水平,改善心功能。Objective To investigate the effect of tirofiban hydrochloride in the treatment of coronary atherosclerotic heart disease(CHD).Methods A total of 120 patients with CHD admitted to the Yancheng First People's Hospital from November 2021 to November 2023 were non-randomly selected as the study objects and divided into two groups according to treatment methods,with 60 cases in each group.All patients received coronary interventional therapy,the control group received conventional anticoagulant therapy after surgery,and the study group received Tirofiban hydrochloride.The efficacy,adverse reactions,cardiac function and vascular endothelial function of the two groups were compared.Results The total effective rate of the study group was 96.67%(58/60),higher than 86.67%(52/60)of the control group,the difference was statistically significant(χ^(2)=3.927,P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The levels of serum inflammatory factors in the study group were better than those in the control group,and the cardiac function and vascular endothelial function were better than those in the control group,the differences were statistically significant(all P<0.05).Conclusion Basic therapy combined with Tirofiban hydrochloride has excellent overall effect in the treatment of coronary heart disease,which can relieve chest asphyxia and chest pain,reduce the level of inflammation and improve heart function.

关 键 词：冠状动脉粥样硬化性心脏病 盐酸替罗非班 治疗效果 不良反应 心功能 血管内皮功能 炎症因子 

分 类 号：R54[医药卫生—心血管疾病]