化疗辅助开腹根治性子宫切除术治疗早期宫颈癌的研究  

Study on the Treatment of Early Cervical Cancer with Open Radical Hysterectomy

作　　者：赵昀辉 罗芹 ZHAO Yunhui;LUO Qin(Department of Obstetrics and Gynecology Oncology,The Third People's Hospital of Honghe Hani and Yi Autonomous Prefecture,Gejiu 661000,Yunnan,China)

机构地区：[1]红河哈尼族彝族自治州第三人民医院妇科肿瘤科,云南个旧661000

出　　处：《系统医学》2024年第22期164-167,共4页Systems Medicine

摘　　要：目的评估化疗辅助开腹根治性子宫切除术在早期宫颈癌治疗中的效果及临床价值。方法非随机选取红河哈尼族彝族自治州第三人民医院于2019年6月—2023年6月收治的180位早期宫颈癌患者为研究对象,按治疗方式不同分为对照组(n=90,开腹根治性子宫切除术治疗)与观察组(n=90,化疗辅助治疗+开腹根治性子宫切除术治疗)。对比两组的手术时间、出血量、术后并发症、肿瘤生物标志物以及淋巴细胞亚群水平。结果观察组的手术时间、出血量以及CD8^(+)水平均低于对照组,CD3^(+)、CD4^(+)水平均高于对照组,差异有统计学意义(P均<0.05)。观察组肿瘤生物标志物水平均低于对照组,差异有统计学意义(P均<0.05)。观察组的并发症发生率为3.33%(3/90),低于对照组的11.11%(10/90),差异有统计学意义(χ^(2)=4.518,P<0.05)。结论化疗辅助开腹根治性子宫切除术在早期宫颈癌患者的治疗中具有积极作用,能够降低肿瘤相关因子水平和术后并发症发生率。Objective To evaluate the efficacy and clinical value of chemotherapy-assisted laparotomy radical hysterectomy in the treatment of early cervical cancer.Methods A total of 180 patients with early cervical cancer admitted to the Third People's Hospital of Honghe Hani and Yi Autonomous Prefecture from June 2019 to June 2023 were non-randomly selected as the study subjects,and divided into control group(n=90,radical open hysterectomy treatment)and observation group(n=90,chemotherapy adjuvant therapy+radical open hysterectomy treatment).Operation time,blood loss,postoperative complications,tumor biomarkers and lymphocyte subsets were compared between the two groups.Results The operation time,blood loss and CD8^(+) level of the observation group were lower than those in control group,and the levels of CD3^(+) and CD4^(+) were higher than those in control group,the differences were statistically significant(all P<0.05).The levels of tumor biomarkers in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).The incidence of complications in the observation group was 3.33%(3/90),lower than 11.11%(10/90)in the control group,and the difference was statistically significant(χ^(2)=4.518,P<0.05).Conclusion Chemotherapy-assisted radical open hysterectomy has a positive effect in the treatment of early cervical cancer,which can reduce the level of tumor-related factors and the incidence of postoperative complications.

关 键 词：早期宫颈癌 开腹根治性子宫切除术 术后并发症 化疗 淋巴细胞亚群水平 

分 类 号：R71[医药卫生—妇产科学]