“双碳”背景下《天然药物化学》实验新探索--光引发自由基制备茚酮化合物  

New Course Exploration on“Natural Medicinal Chemistry”Experiment under the Background of“Double Carbon”:Preparation of Indenone Compounds by Photo-initiated Radical

作　　者：冯亚栋 陈芳芳 陈煜沛 王贵弘 Feng Yadong;Chen Fangfang;Chen Yupei;Wang Gueyhorng(Xiamen Medical College,Department of Public Health and Medical Technology,Engineering Research Center of Natural Cosmeceuticals College of Fujian Province,Xiamen 361023,China)

机构地区：[1]厦门医学院公共卫生与医学技术系天然化妆品福建省高校工程研究中心,福建厦门361023

出　　处：《广东化工》2024年第24期138-140,共3页Guangdong Chemical Industry

基　　金：厦门医学院2023年教育教学改革研究项目“应用型高校化妆品专业天然物化学课程教学改革研究”(XBYX2023009);厦门市自然科学基金(3502Z202372064)。

摘　　要：本文在“双碳”战略目标的关键背景下,对《天然药物化学》实验开展新探索,让学生理解绿色药物合成的理念,增强学习兴趣,提高教学质量。本次课程探索旨在教育学生在无金属催化剂的条件下,设计采用紫外光引发生成酰基自由基,继而与自由基受体炔烃发生级联环化反应,制备天然药物化学中重要的天然药物衍生物2,3-二苯基-5-甲基-1-茚酮。通过柱色谱对产物进行分离纯化,通过核磁共振对产物结构进行鉴定,通过对照试验进行反应机理探索。实验过程中通过讲解光催化自由基反应理论和应用,使学生体会绿色化学理念,掌握学以致用的道理,提高学习兴趣,培养解决实际专业问题的能力,同时达到提高教学质量的目的。Under the key background of the“two-carbon”strategic goal,this paper carries out a new exploration of the experiment of“Natural Pharmaceutical Chemistry”,so that students can understand the concept of green drug synthesis,enhance learning interest and improve teaching quality.The purpose of this course is to educate students in the design of acyl radical formation by ultraviolet light in the absence of metal catalyst,and then cascade cyclation reaction with free radical receptor alkyne to prepare 2,3-diphenyl-5-methyl-1-indone,an important natural drug derivative in natural pharmaceutical chemistry.The product was separated and purified by column chromatography,the structure of the product was identified by nuclear magnetic resonance,and the reaction mechanism was explored by the control experiment.During the experiment,through explaining the theory and application of photocatalytic free radical reaction,students can understand the concept of green chemistry,master the principle of applying what they have learned,improve their interest in learning,cultivate their ability to solve practical professional problems,and achieve the purpose of improving the teaching quality.

关 键 词：天然药物化学 实验探索 教学改革 

分 类 号：TQ423.2[化学工程]