化妆品中氧化铈纳米颗粒检测方法研究  

Research on the Determination Method of Cerium Oxide Nanoparticles in Cosmetics

作　　者：李莉[1] 李硕 李庆武[2] 樊昌俊 王海燕[1] LI Li;LI Shuo;LI Qing-wu;FAN Chang-jun;WANG Hai-yan(NMPA Key Laboratory for Research and Evaluation of Cosmetics,National Institutes for Food and Drug Control,Beijing 100050,China;National Institute of Metrology,Beijing 100029,China;Shimadzu(China)Co.,Ltd.,China Innovation Center,Beijing 100020,China)

机构地区：[1]中国食品药品检定研究院国家药品监督管理局化妆品研究与评价重点实验室,北京100050 [2]中国计量科学研究院,北京100029 [3]岛津企业管理(中国)有限公司创新中心,北京100020

出　　处：《分析测试学报》2024年第12期1944-1951,共8页Journal of Instrumental Analysis

基　　金：中国食品药品检定研究院中青年发展研究基金课题资助项目(2018C02);中国计量科学研究院基本科研业务费项目(AKYZZ2443)。

摘　　要：初步建立了单颗粒电感耦合等离子体质谱(spICP-MS)测定化妆品中纳米氧化铈颗粒粒径大小及分布的方法。以0.1%Triton X-100为萃取剂超声辅助提取化妆品中的纳米氧化铈颗粒,在脉冲信号模式下采集数据并通过计算得到颗粒粒径大小及分布。探讨了spICP-MS用于检测化妆品中纳米颗粒时,不同计算方法对颗粒粒径检出限的影响。实验结果表明:粒径检出限不仅受到待测同位素背景信号的影响,也与化妆品基质相关。选择不同的计算方法时,粒径检出限及被识别为颗粒的个数均受到显著影响,直接关系到化妆品产品的合规性判定及安全性评价。阈值的准确选择是影响spICP-MS用于化妆品中纳米级颗粒存在与否判定的重要因素,应在现有化妆品基质分类的基础上,根据样品性质进行进一步评估。该方法可用于防晒类化妆品中纳米氧化铈颗粒的快速筛查,并可对其粒径大小及分布进行同时测定和表征,为含纳米颗粒化妆品的合规性和安全性考察提供了可供探讨的空间和途径。A method was initially developed for the determination of particle size and distribution of cerium oxide nanoparticles in cosmetics using single particle inductively coupled plasma-mass spectrometry(spICP-MS).0.1% Triton X-100 was employed as an extractant for ultrasound-assisted extraction of cerium oxide nanoparticles in cosmetics.The data were acquired in pulse signal mode,and the particle size and distribution were determined through calculation.The effect of different calculation methods on the detection limit of particle size when spICP-MS is used for the detection of nanoparticles in cosmetics was further investigated.The experimental results demonstrated that the lower limit of particle size detection was influenced not only by the background signal of the isotope to be detected but also by the cosmetic matrix.Different background thresholds significantly affected both the lower limit of particle size detection and the number of identified particles,thereby directly impacting compliance and safety considerations for cosmetics.The accurate selection of the threshold value is an important factor in the determination of the presence or absence of nanoscale particles in cosmetics by sampling spICP-MS for cosmetic use,which should be further evaluated on the basis of the existing classification of cosmetic matrices,depending on the nature of the sample.This method enables rapid screening of cerium dioxide nanoparticles in sunscreen cosmetics while simultaneously determining and characterizing their particle size and distribution,providing a framework for discussing compliance and safety investigations regarding nanoparticle-containing cosmetics.

关 键 词：单颗粒电感耦合等离子体质谱法 纳米氧化铈(CeO_(2)-NP) 背景阈值 化妆品 

分 类 号：O657.6[理学—分析化学] TQ658[理学—化学]