一种亚胺键的壳聚糖基水凝胶的设计与合成  

Design and Synthesis of a Chitosan-based Hydrogels Based on Imine Bond

作　　者：罗小艳 黄诗雅 郑楚楚 章莉娟[1] Luo Xiaoyan;Huang Shiya;Zheng Chuchu;Zhang Lijuan(Guangdong Provincial Key Lab of Green Chemical Product Technology,School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou 510640,China)

机构地区：[1]华南理工大学化学与化工学院广东省绿色化学产品技术重点实验室,广东广州510640

出　　处：《广东化工》2024年第21期47-49,101,共4页Guangdong Chemical Industry

基　　金：国家自然科学基金(21978105)。

摘　　要：设计合成了羧甲基壳聚糖(CMC)与二醛基原酸酯(CHO-OE-CHO)单体。羧甲基壳聚糖(CMC)单体极大地改善了壳聚糖的水溶性,并保留了大量氨基参与水凝胶的形成。两端均为醛基的原酸酯单体(CHO-OE-CHO)具有较强的酸敏感特性,能在弱酸性条件下水解。两种凝胶因子CMC与CHO-OE-CHO在水中能自发形成亚胺键,构建CHO-OE-CHO/CMC水凝胶网络。采用傅里叶红外光谱表征水凝胶的分子结构,显示水凝胶的形成与亚胺键自发成键有关。扫描电镜的测试结果表明,CHO-OE-CHO/CMC水凝胶呈三维网状结构,具有较多的孔隙,在医用敷料领域具有一定的应用潜质。We designed and synthesized two monomers of carboxymethyl chitosan(CMC) and ortho ester dialdehyde(CHO-OE-CHO).CMC greatly improved the water solubility,and retained a large number of amino groups to participate in the formation of hydrogel.CHO-OE-CHO had acid-sensitivity and could be hydrolyzed under acidic conditions.Two gel factors,CMC and CHO-OE-CHO,could construct CHO-OE-CHO/CMC hydrogel network spontaneously by imine bonds.FT-IR was used to characterize the structure of hydrogel,which proved that the formation of hydrogel was related to the spontaneous bonding of imine bonds.The image of SEM showed that the CHO-OE-CHO/CMC hydrogel had three-dimensional network structure with many gaps,which has potential application for medical dressings.

关 键 词：水凝胶 医用敷料 亚胺键 壳聚糖 原酸酯键 

分 类 号：TQ[化学工程]