重组人表皮生长因子联合纳米银敷料治疗烧伤的效果及对炎症状态的改善分析  

Effect of recombinant human epidermal growth factor combined with nano-silver dressing on flburn and improvement of inflammatory state

作　　者：戚明 陶勇 张杰 张永雷 俞夏 QI Ming;TAO Yong;ZHANG Jie;ZHANG Yonglei;YU Xia(Department of Trauma Rehabilitation and Cosmetology,Xinyi People's Hospital,Jiangsu Province,221400,China)

机构地区：[1]新沂市人民医院创伤整复美容科,江苏新沂221400

出　　处：《中国医疗美容》2024年第11期73-76,共4页China Medical Cosmetology

摘　　要：目的研究分析烧伤采取重组人表皮生长因子(rhEGF)联合纳米银敷料治疗的临床效果及对炎症状态的改善作用。方法选取我院在2021年7月-2024年9月期间收治的25例烧伤患者,所有患者均需要采取rhEGF联合纳米银敷料治疗。比较观察患者的血清炎症水平、疼痛程度、创面愈合时间、不良反应和治疗满意度评价。结果治疗后的TNF-α、ICAM-1、NRS评分低于治疗前,IL-10高于治疗前,差异有统计学意义(P<0.05);20例患者创面愈合50%时间(10.89±2.37)d,愈合80%时间(16.42±5.19)d,愈合100%时间(20.93±5.27)d;治疗期间瘙痒、红肿、主观感觉烧灼感分别发生1例、1例、2例,不良反应总发生率16.00%(4/25);患者对本次治疗方案感到满意评价为96.00%(24/25)。结论在烧伤的临床治疗中,rhEGF联合纳米银敷料能够有效减轻疼痛程度,改善炎症状态,促进创面愈合,且该治疗方案具有操作简便的特点,在临床中的应用价值较高。Objective To study the analysis of burns to recombinant human epidermal growth factor(rhEGF),the clinical effect of combined therapy with nano silver dressing and the effect on the improvement of the inflflammatory state.Methods A total of 25 burn patients admitted to our hospital from July 2021 to September 2024 were selected.All patients were treated with rhEGF combined with nano-silver dressing.The serum inflflammation level,pain degree,wound healing time,adverse reactions and treatment satisfaction were compared and observed.Results The scores of TNF-α,ICAM-1,and NRS after treatment were lower than before treatment,while IL-10 was higher than before treatment,and the differences were statistically signifificant(P<0.05).The wound healing time of 20 patients was 50%(10.89±2.37)d,80%(16.42±5.19)d,100%(20.93±5.27)d.Pruritus,redness,and subjective sensation of burning occurred in 1 case,1 case,and 2 cases,respectively.The total incidence of adverse reactions was 16.00%(4/25).96.00%of the patients were satisfified with the treatment plan(24/25).Conclusions In the clinical treatment of burn,rhEGF combined with nano-silver dressing can effectively reduce the degree of pain,improve the inflflammatory state,and promote wound healing,and this treatment program has the characteristics of simple operation,and has high clinical application value.

关 键 词：重组人表皮生长因子 纳米银敷料 烧伤 炎症状态 

分 类 号：R644[医药卫生—外科学]