血管紧张素受体脑啡肽酶抑制剂治疗高血压的有效性和安全性的Meta分析  

Meta-analysis of efficacy and safety of angiotensin receptor-neprilysin inhibitor for hypertension

作　　者：陈晨[1,2,3] 陈钰灵 王棋 赵梦男 吴斌 徐珽[1,3] CHEN Chen;CHEN Yuling;WANG Qi;ZHAO Mengnan;WU Bin;XU Ting(Department of Pharmacy,West China Hospital,Sichuan University,Sichuan Chengdu 610041,China;Chinese Evidence-Based Medicine Center,West China Hospital of Sichuan University,Sichuan Chengdu 610041,China;West China School of Pharmacy,Sichuan University,Sichuan Chengdu 610041,China)

机构地区：[1]四川大学华西医院临床药学部(药学科),四川成都610041 [2]四川大学华西医院中国循证医学中心,四川成都610041 [3]四川大学华西药学院,四川成都610041

出　　处：《中国医院药学杂志》2024年第22期2640-2646,2654,共8页Chinese Journal of Hospital Pharmacy

基　　金：2022年四川省干部保健科研课题(编号:川干研2022-119)。

摘　　要：目的:探究高血压患者使用血管紧张素受体脑啡肽酶抑制剂的有效性和安全性。方法:通过系统检索中国知网、万方、维普、中国生物医学文献数据库、Medline、Embase和Central,检索时间为建库至2023年11月5日,患者诊断为高血压,采用RoB2进行文献质量评价。结果:共纳入13项随机对照试验,涉及9 155名高血压患者,荟萃分析结果显示,与对照组相比,血管紧张素受体脑啡肽酶抑制剂可以显著降低高血压患者的平均坐位收缩压[WMD=–5.75,95%CI(–7.04,–4.45)]和平均坐位舒张压[WMD=–2.80,95%CI(–3.60,–1.99)],且未增加不良事件的发生风险[总不良事件:RR=1.02,95%CI(0.96,1.09),严重不良事件:RR=0.81,95%CI(0.54,1.23)]。结论:血管紧张素受体脑啡肽酶抑制剂具有显著的降压作用,安全性良好。OBJECTIVE To explore the efficacy and safety of angiotensin receptor-neprilysin inhibitor(ARNI)in hyperten-sive patients.METHODS Through the systematic searches of China National Knowledge Infrastructure(CNKI),Wanfang,VIP,China Biomedical Literature Database,Medline(Ovid),Embase(Ovid)and Central(Ovid),retrieval time started from the establishment of database until November 5,2023.Literature quality was evaluated by RoB2.RESULTS A total of 13 ran-domized controlled trials involving 9155 hypertensive patients were included.The results indicated that,as compared with control group,ARNIs significantly lowered mean sitting systolic blood pressure[WMD=-5.75,95%CI(-7.04,-4.45)]and mean sit-ting diastolic blood pressure[WMD=-2.80,95%CI(-3.60,-1.99)].And it did not elevate the risk of adverse events[total adverse events:RR=1.02,95%CI(0.96,1.09),serious adverse events:RR=0.81,95%CI(0.54,1.23)].CONCLUSION ARNIs have significant antihypertensive effects with excellent safety.

关 键 词：高血压 血管紧张素受体脑啡肽酶抑制剂 META分析 

分 类 号：R972[医药卫生—药品]