芪参止眩方治疗后循环缺血性孤立性眩晕的随机对照试验  

Randomized controlled trial of Qishen Zhixuan Formula in treating posterior circulation ischemia-induced isolated vertigo

作　　者：郝姗姗 王娟 谢春荣 王冉 张肖 HAO Shanshan;WANG Juan;XIE Chunrong;WANG Ran;ZHANG Xiao(Encephalopathy Department,Beijing Huairou Hospital of Traditional Chinese Medicine,Beijing 101400,China)

机构地区：[1]北京中医医院怀柔医院脑病科,北京101400

出　　处：《湖南中医药大学学报》2024年第11期2056-2060,共5页Journal of Hunan University of Chinese Medicine

基　　金：北京市医院管理中心基金项目(PZ20211022)。

摘　　要：目的探讨芪参止眩方治疗后循环缺血性孤立性眩晕的疗效及对超敏-C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、白细胞介素-6(interleukin-6,IL-6)、D-二聚体(D-dimer,DD)的影响。方法选取2022年1月至2023年12月于北京中医医院怀柔医院脑病科就诊的97例后循环缺血性孤立性眩晕患者,依据随机数字表法随机分为对照组(n=48)与研究组(n=49)。对照组予常规西医治疗,研究组在对照组基础上加芪参止眩方治疗,疗程均为2周。比较两组疗效、中医证候积分、头晕残障问卷量表(dizziness handicap inventory,DHI)评分及血清hs-CRP、IL-6、DD的变化。结果研究组有效率(95.74%)高于对照组(78.26%);中医证候积分、DHI评分的改善情况均优于对照组(P<0.05);hs-CRP、IL-6、DD较对照组下降更明显(P<0.05);两组患者均未出现肝肾功能异常及过敏反应。结论采用芪参止眩方治疗后循环缺血性孤立性眩晕,可以改善患者中医证候,减轻眩晕症状,提高疗效,并能降低hs-CRP、IL-6和DD水平。Objective To investigate the efficacy of Qishen Zhixuan Formula(QSZXF)in treating posterior circulation ischemia-induced isolated vertigo and its effects on hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),and D-dimer(DD).Methods A total of 97 patients with posterior circulation ischemia-induced isolated vertigo who presented the Encephalopathy Department of Beijing Huairou Hospital of Traditional Chinese Medicine from January 2022 to December 2023 were randomized into control group(n=48)and research group(n=49)using random number table method.The control group received conventional Western medicine treatment,while the research group was treated with QSZXF in addition to the treatment of control group.The treatment course lasted for two weeks for both groups.The efficacy,traditional Chinese medicine syndrome scores,dizziness handicap inventory(DHI)score,and changes in serum hs-CRP,IL-6,and DD levels were compared between the two groups.Results The effective rate of the research group(95.74%)was higher than that of the control group(78.26%);the improvement in the traditional Chinese medicine syndrome scores and DHI scores of the research group was better than that of the control group(P<0.05);hs-CRP,IL-6,and DD levels of the research group decreased more significantly compared to those in the control group(P<0.05);no patients in either group experienced any liver or kidney dysfunction or allergic reactions.Conclusion The treatment with QSZXF for posterior circulation ischemia-induced isolated vertigo can relieve symptoms of the CM pattern,alleviate vertigo,enhance therapeutic efficacy,and reduce levels of hs-CRP,IL-6,and DD in patients.

关 键 词：芪参止眩方 后循环缺血性孤立性眩晕 超敏-C反应蛋白 白细胞介素-6 D-二聚体 

分 类 号：R255.3[医药卫生—中医内科学]