右美托咪定对腹部手术全身麻醉患者围拔管期血流动力学及苏醒过程的影响  

Effects of dexmedetomidine on hemodynamics and awakening process during extubation in patients underwent general anesthesia for abdominal surgery

作　　者：张春燕 张雁 ZHANG Chunyan;ZHANG Yan(Surgical Anesthesiology Department,Henan Electric Power Hospital,Zhengzhou 450052,China)

机构地区：[1]河南电力医院手术麻醉科,河南郑州450052

出　　处：《临床医学研究与实践》2024年第34期99-102,共4页Clinical Research and Practice

摘　　要：目的分析右美托咪定对腹部手术全身麻醉患者围拔管期血流动力学及苏醒过程的影响。方法纳入我院2022年1月至12月收治的104例腹部手术全身麻醉患者为研究对象,根据麻醉方案差异将其分为常规组(52例,手术结束前30 min应用生理盐水)和观察组(52例,手术结束前30 min应用右美托咪定)。比较两组的干预效果。结果入室时(T_(0)),两组的心率(HR)无显著差异(P>0.05);麻醉用药5 min后(T_(1))~拔管10 min后(T_(5)),观察组的HR显著低于常规组(P<0.05);T_(0)~T_(1),两组的收缩压(SBP)、舒张压(DBP)无显著差异(P>0.05);麻醉用药10 min后(T2)~T_(5),观察组的SBP、DBP显著低于常规组(P<0.05);T_(0),两组的平均动脉压(MAP)、中心静脉压(CVP)无显著差异(P>0.05);T_(1)~T_(5),观察组的MAP、CVP显著高于常规组(P<0.05);T_(0)~T_(5),两组的脑电双频指数(BIS)无显著差异(P>0.05)。观察组的呼吸恢复时间、按指令睁眼时间、拔除气管导管时间短于常规组,术后2 h视觉模拟评分量表(VAS)评分及术后围拔管期不良反应总发生率低于常规组(P<0.05)。结论右美托咪定用于腹部手术全身麻醉患者中,可在保障麻醉效果的同时,稳定围拔管期的血流动力学,缩短苏醒过程,减少不良反应。Objective To analyze the effects of dexmedetomidine on the hemodynamics and awakening process during extubation in patients underwent general anesthesia for abdominal surgery.Methods A total of 104 patients underwent general anesthesia for abdominal surgery admitted in our hospital from January to December 2022 were included as the study objects.According to the difference of anesthesia scheme,the patients were divided into conventional group(52 cases,normal saline was applied at 30 min before the end of surgery)and observation group(52 cases,dexmedetomidine was applied at 30 min before the end of surgery).The intervention effects of the two groups were compared.Results When entering the room(T_(0)),there was no significant difference in heart rate(HR)between the two groups(P>0.05);after 5 min of anesthesia medication(T_(1))-after 10 minutes of extubation(T_(5)),HR of the observation group was significantly lower than that of the conventional group(P<0.05);T_(0)-T_(1),there were no significant differences in systolic blood pressure(SBP)and diastolic blood pressure(DBP)between the two groups(P>0.05);after 10 min of anesthesia medication(T2)-T_(5),SBP and DBP in the observation group were significantly lower than those in the conventional group(P<0.05);T_(0),there were no significant differences in mean artery pressure(MAP)and central venous pressure(CVP)between the two groups(P>0.05);T_(1)-T_(5),MAP and CVP of the observation group were significantly higher than those of the conventional group(P<0.05);T_(0)-T_(5),there was no significant difference in bispectral index(BIS)between the two groups(P>0.05).The respiratory recovery time,eye opening time according to instructions and extubation time in the observation group were shorter than those in the conventional group,and the Visual Analogue Scale(VAS)score at 2 h after operation and the total incidence of adverse reactions during extubation were lower than those in the conventional group(P<0.05).Conclusion Dexmedetomidine can stabilize the hemodynamics during extu

关 键 词：腹部手术 全身麻醉 右美托咪定 血流动力学 

分 类 号：R654.2[医药卫生—外科学]