Specific convulsions and brain damage in children hospitalized for Omicron BA.5 infection:an observational study using two cohorts  

作　　者：Yuan-Yuan Pei Hong-Li Wang Gen-Quan Yin Yi Xu Jian-Hao Tan Xin-Hua Liang Hui-Ying Wu Xun-Tao Yin Chun-Xiao Fang Jun-Zheng Peng Zhi-Yuan Wu Yi Sun Run Dang Yu-Feng Liang Hong-Mei Tang You-Yi Li Zhong-Xiang Qiao Zhi-Cheng Liang Jian-Ping Tang Fan-Sen Zeng Ke-Lu Zheng Yi-Ru Zeng Xiao-Jun Cao Hui-Min Xia Jian-Rui Wei Jin-Ling Tang Si-Tang Gong 

机构地区：[1]Clinical Data Center,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China [2]Department of Gastroenterology,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China [3]Department of Internal Medicine,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China [4]Department of Infectious Diseases,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China [5]Information Department,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China [6]School of Pediatrics,Guangzhou Medical University,Guangzhou 510623,China [7]Imaging Department,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China [8]Respiratory Department,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China [9]Pediatric Intensive Care Unit,Guangzhou Women and Children’s Medical Center,Guangzhou Medical University,Guangzhou,510623,China [10]Neonatal Intensive Care Unit,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China [11]Rehabilitation Department,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China [12]General Pediatrics,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou510623,China [13]Emergency Department,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China [14]Department of Neurology,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China [15]Key Laboratory of Structural Birth Defects Research in Guangdong Province,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China [16]Cardiovascular Department,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China [17]Shenzhen Inst

出　　处：《World Journal of Pediatrics》2024年第10期1079-1089,共11页世界儿科杂志（英文版）

基　　金：supported by the Science and Technology Planning Project of Guangdong Province(No.2020B1111170001);The funder had no role in the study design,data collection and analysis,decision to publish,or preparation of the manuscript.

摘　　要：Background SARS-CoV-2 continues to mutate over time,and reports on children infected with Omicron BA.5 are limited.We aimed to analyze the specific symptoms of Omicron-infected children and to improve patient care.Methods We selected 315 consecutively hospitalized children with Omicron BA.5 and 16,744 non-Omicron-infected febrile children visiting the fever clinic at our hospital between December 8 and 30,2022.Specific convulsions and body temperatures were compared between the two cohorts.We analyzed potential associations between convulsions and vaccination,and additionally evaluated the brain damage among severe Omicron-infected children.Results Convulsion rates(97.5%vs.4.3%,P<0.001)and frequencies(median:2.0 vs.1.6,P<0.001)significantly differed between Omicron-infected and non-Omicron-infected febrile children.The body temperatures of Omicron-infected children were significantly higher during convulsions than when they were not convulsing and those of non-Omicron-infected febrile children during convulsions(median:39.5 vs.38.2 and 38.6℃,both P<0.001).In the three Omicron-subgroups,the temperature during convulsions was proportional to the percentage of patients and significantly differed(P<0.001),while not in the three non-Omicron-subgroups(P=0.244).The convulsion frequency was lower in the 55 vaccinated children compared to the 260 non-vaccinated children(average:1.8 vs.2.1,P<0.001).The vaccination dose and convulsion frequency in Omicron-infected children were significantly correlated(P<0.001).Fifteen of the 112 severe Omicron cases had brain damage.Conclusions Omicron-infected children experience higher body temperatures and frequencies during convulsions than those of non-Omicron-infected febrile children.We additionally found evidence of brain damage caused by infection with omicron BA.5.Vaccination and prompt fever reduction may relieve symptoms.

关 键 词：Body temperature Brain damage:Children:Convulsion Omicron BA.5.Vaccination 

分 类 号：R725.1[医药卫生—儿科]