Assay of Biomarkers for Alzheimer’s Disease by Surface Plasmon Resonance  

作　　者：Xinyao Yi Huihui Chen Yuhan He Jianxiu Wang 

机构地区：[1]Hunan Provincial Key Laboratory of Micro and Nano Materials Interface Science,College of Chemistry and Chemical Engineering,Central South University,Changsha,410083,China

出　　处：《Journal of Analysis and Testing》2024年第3期251-261,共11页分析检测（英文）

基　　金：the financial support of this work by the National Natural Science Foundation of China(22076221,21876208);the Central South University Innovation-Driven Research Programme(2023CXQD022);the Hunan Provincial Science and Technology Plan Project,China(2019TP1001).

摘　　要：Alzheimer’s disease(AD)is one of the neurodegenerative diseases characterized by cognitive dysfunction and behavioral impairment.Early diagnosis of AD serves as a viable means to avoid the onset and progression of the disease.Due to the remarkably lower expression levels of AD biomarkers in cerebrospinal fluids and serum samples,sensitive and specific analytical methods are highly demanded.Surface plasmon resonance(SPR)is ultrasensitive to the refractive index or thickness change at the metal surface,which enables real-time and label-free assay of target biomolecules.In this review,we summarize the advances on assay of AD biomarkers including amyloid beta,tau protein,apoE proteins and apoE genes,and BACE1 by SPR,with emphasis on the analytical performances concerning anti-fouling and signal amplification strategies and real sample applications.

关 键 词：Surface plasmon resonance Alzheimer’s disease amyloid beta Tau protein apoE BACE1 

分 类 号：O657[理学—分析化学] R749.16[理学—化学]