Integrating Bimetallic Nanoparticles with Covalent Organic Frameworks as Multifunctional Nanozyme for Colorimetric Detection of Hydrogen Peroxide and Glutathione  

作　　者：Yuying Yuan Xiaoxue Xi Ting Bao Pingguan Bian Feng Pei Xiuhua Zhang Shengfu Wang Wei Wen 

机构地区：[1]Collaborative Innovation Center for Advanced Organic Chemical Materials,Co-constructed by the Province and Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules,College of Chemistry and Chemical Engineering,Hubei University,Wuhan,430062,China [2]Hubei Yihua Chemical Co.,Ltd,Yichang,443000,China

出　　处：《Journal of Analysis and Testing》2024年第3期278-287,共10页分析检测（英文）

基　　金：financially supported by the National Natural Science Foundation of China(22076041,22076042);the Key Research and Development Program of Hubei Province,China(2023BAB134).

摘　　要：The controllable growth of metal nanoparticles on nanomaterials is becoming an effective strategy for developing nanocomposites with designated performance.Herein,a simple and mild strategy for the in situ growth of Pt–Pd bimetallic nanoparticles on covalent organic frameworks(COFs)to regulate the nanozyme activity was designed for colorimetric detection of hydrogen peroxide(H2O2)and glutathione(GSH).The COFs not only offer sufficient loading sites for the uniform dispersion of Pt–Pd bimetallic nanoparticles,but also increase the adsorption of substrate to promote the catalytic reaction.With the bimetallic synergistic effect of Pt–Pd nanoparticles,the prepared multifunctional nanozyme(Pt–Pd/COFs nanozyme)simultaneously exhibited superior peroxidase(POD)-like activity and oxidase(OXD)-like activity.Using the multifunctional nanozyme,a colorimetric sensing system was constructed for sensitive detection of H2O2 and GSH,with the wide linear ranges of 5–1000µmol/L and 1–40µmol/L,and the detection limits were 1.14μmol/L and 0.43μmol/L,respectively.It was successfully used for the detection of real samples in environmental water and serum,providing a simple method for disease diagnosis and environmental monitoring.

关 键 词：Pt-Pd/COFs nanozyme Bimetallic synergistic effect Peroxidase-like activity Oxidase-like activity H_(2)O_(2)and GSH detection 

分 类 号：TB383.1[一般工业技术—材料科学与工程] O657.3[理学—分析化学]