Multifunctional Peptide-Melanin Hybrid Nanodots with Robust Anti-Cutaneous Photoaging Activity  

作　　者：Peizhe Li Qiming Zhu Baozhu Wang Shanshan He Qi Xu Kaiyan Li Yongmiao Shen Miao Su Zhijun Zhang 

机构地区：[1]Key Laboratory of Surface&Interface Science of Polymer Materials of Zhejiang Province,School of Chemistry and Chemical Engineering,Zhejiang Sci-Tech University,Hangzhou,310018,China [2]College of Textile Science and Engineering(International Silk Institute),Zhejiang Sci-Tech University,Hangzhou,310018,China [3]Shanghai Beautyart Biotechnology Co.,Ltd,Shanghai,200438,China [4]Shengzhou Innovation Research Institute of Zhejiang Sci-Tech University,Shengzhou,312400,China

出　　处：《Journal of Analysis and Testing》2024年第3期395-401,共7页分析检测（英文）

基　　金：financially supported by National Natural Science Foundation of China(NSFC)(22007083);Wenzhou Major Science and Technology Innovation Project(ZZN2023002);the Fundamental Research Funds of Shengzhou Innovation Research Institute of Zhejiang Sci-Tech University(SYY2023B000004);the Fundamental Research Funds of Zhejiang Sci-Tech University(24262132-Y).

摘　　要：Skin aging is a systematic and complex process,mainly including intrinsic aging caused by time change and extrinsic aging caused by environmental factors.Photoaging caused by ultraviolet(UV)irradiation is the principle extrinsic factor of skin aging,which can directly or indirectly cause damage to DNA and other biomolecules,generate reactive oxygen species(ROS),and induce a decrease in collagen synthesis and other adverse effect.Herein,to address the causative factors and multiple side effects of skin photoaging,we constructed multifunctional peptide-melanin hybrid nanodots(PMHDs)to achieve multifaceted synergistic anti-skin aging by using melanin-like nanodots(MDs)and functional peptides as active motifs.Among them,the peptide has the activity of promoting collagen synthesis,while the MDs have the function of absorbing UV light and scavenging free radicals.Additionally,the MDs also act as a carrier to increase the cellular uptake of the peptide.The anti-photoaging effects of the PMHDs were systematically verified in a multidimensional manner at the biochemical,cellular and small animal levels,respectively.

关 键 词：aging SKIN ULTRAVIOLET 

分 类 号：TB383.1[一般工业技术—材料科学与工程]