肠道微生态制剂在老年肌少症中的应用研究进展  

Progress in the application of intestinal microecological preparations in the treatment of senile sarcopenia

作　　者：杨伟(综述)[1] 李静(审校)[1] Yang Wei;Li Jing(Department of Geriatrics,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院老年医学科,北京100053

出　　处：《疑难病杂志》2024年第12期1533-1536,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：首都卫生发展科研专项自主创新项目(2024-2-1033);北京市属医院科研培育计划项目(PX2022032);北京市属医学科研院所公益发展改革试点项目(JYY2023-13)。

摘　　要：肌少症是一种伴随衰老出现的骨骼肌量及功能衰退病症,影响老年人的身体活动能力和生活质量。肠道微生物群的健康状态对于维持肌肉质量和功能至关重要,随着年龄的增长,肠道屏障功能减弱,导致慢性低度炎性反应,进而加速肌肉组织的流失。益生菌、益生元及合生元作为调节肠道微生物平衡的关键成分,能够抑制有害菌生长,减少促炎因子的产生,同时促进短链脂肪酸生成,从而增强肌肉合成代谢过程,对抗肌少症的发展。因此,文章对肠道微生态制剂在老年肌少症中的应用实验和临床研究进行综述。Sarcopenia is a generalized,progressive age-related skeletal muscle disorder characterized by decreased muscle mass and strength,significantly impacts elderly individuals'physical activity capabilities and quality of life.Recent studies highlight that the health status of the gut microbiota is crucial for maintaining muscle mass and function.With advancing age,intestinal barrier functions weaken,leading to chronic low-grade inflammation,which accelerates the depletion of muscle tissue.Probiotics,prebiotics,and synbiotics,as key components for regulating gut microbial balance,can inhibit the growth of pathogenic bacteria,reduce the production of pro-inflammatory factors,and promote the generation of short-chain fatty acids,thereby enhancing muscle anabolic processes and resisting the progression of sarcopenia.This article reviews experimental and clinical research both domestically and internationally regarding gut microbiome preparations,underscoring their potential role in combating age-related muscle loss.

关 键 词：老年肌少症 微生态制剂 肠道微生物 研究进展 

分 类 号：R685[医药卫生—骨科学]