急性心肌梗死患者不同CSI对血清cTnI、H-FABP、CK-MB水平的影响及与心脏超声特点的相关性研究  

The influence of different CSI on serum cTnI,H-FABP,CK-MB levels in patients with acute myocardial infarction and its correlation with cardiac ultrasound characteristics

作　　者：梁微 张尧平 刘佳 赵高芳 陈秀琼 LIANG Wei;ZHANG Yaoping;LIU Jia;ZHAO Gaofang;CHEN Xiuqiong(Department of Medical Ultrasound,Mianyang 404 Hospital,Mianyang 621000,Sichuan,China;Department of Laboratory,Jiange People's Hospital,Guangyuan 628300,Sichuan,China)

机构地区：[1]四川绵阳四〇四医院医学超声科,四川绵阳621000 [2]剑阁县人民医院检验科,四川广元628300

出　　处：《西部医学》2024年第12期1863-1867,共5页Medical Journal of West China

基　　金：2020年绵阳市卫健委科研课题(202053)。

摘　　要：目的 探究急性心肌梗死(AMI)患者不同声学造影积分指数(CSI)对血清肌钙蛋白I(cTnI)、心脏型脂肪酸结合蛋白(H-FABP)、肌酸激酶同工酶(CK-MB)水平的影响及与心脏超声特点的相关性研究。方法 选取2019年3月—2021年3月四川绵阳四○四医院收治的90例AMI患者,患者均接受心肌声学造影检查(MCE),并以检查结果作为患者心肌灌注水平的评价标准,根据患者的CSI将所有患者分为A组(CSI≥0.75,n=50)和B组(CSI<0.75,n=40)。所有患者均进行心脏超声检查,检测患者血清cTnI、H-FABP、CK-MB等心肌损伤标志物水平,并探究患者心脏超声特点与心肌灌注水平间的相关性。结果 B组LA、LVD值高于A组,E、A、E/A、LVEF值低于A组(P<0.05),两组间LVMI比较差异无统计学意义(P>0.05)。B组患者的cTnI、H-FABP、CK-MB水平均高于A组患者(P<0.05)。经相关性分析可知患者LA、LVD、LVEF水平与心肌灌注水平呈负相关(P<0.05),E、E/A与患者心肌灌注水平呈正相关(P<0.05)。结论 AMI患者心脏超声特点与心肌灌注水平具有一定相关性,CSI评分越低,患者的LA、LVD、LVEF水平越高,E、E/A值越低,患者的心肌损伤标志物水平越高。Objective To explore the effects of different contrast acoustic scores(CSI)on serum troponin I(cTnI),cardiac fatty acid binding protein(H-FABP)and creatine kinase isoenzyme(CK-MB)levels in patients with acute myocardial infarction(AMI)and their correlation with cardiac ultrasound characteristics.Methods Ninety patients with AMI admitted to our hospital from March 2019 to March 2021 were selected.All patients received myocardial contrast acoustic examination(MCE),and the examination results were used as the evaluation criteria for the myocardial perfusion level of patients.According to the patients'CSI,all patients were divided into group A(CSI≥0.75,n=50)and group B(CSI<0.75,n=40).All patients underwent cardiac ultrasound examination to detect the levels of serum markers of myocardial injury such as cTnI,H-FABP and CK-MB,and to explore the correlation between the characteristics of cardiac ultrasound and the level of myocardial perfusion.Results There were statistical differences in LA,LVD,LVEF,E,A,E/A between the two groups,and the values of LA,LVD in group B were higher than those in group A,and the values of E,A,E/A,LVEF were lower than those in group A(P<0.05),but there was no statistically significant difference in LVMI between the two groups(P>0.05).There were statistical differences in the levels of cTnI,H-FABP and CK-MB between the two groups,and the levels in group B were higher than those in group A(P<0.05).Correlation analysis showed that the levels of LA,LVD and LVEF were negatively correlated with the level of myocardial perfusion,while E and E/A were positively correlated with the level of myocardial perfusion.Conclusion There is a correlation between cardiac ultrasound characteristics and myocardial perfusion level in AMI patients,the lower the CSI score,the higher LA,LVD,LVEF levels,and lower E and E/A values,and the higher the level of myocardial injury markers.

关 键 词：急性心肌梗死 心肌灌注水平 心脏超声 相关性 

分 类 号：R541[医药卫生—心血管疾病] R816.2[医药卫生—内科学]