复方利多卡因乳膏不同给药时间对<3月龄婴儿腰椎穿刺术的镇痛效果  

Analgesic effect of different administration time of compound lidocaine cream for lumbar paracentesis in infants<3 months old

作　　者：沈雪萍 刘珏 徐莉莉 佘亚娥 滕懿群 SHEN Xueping;LIU Jue;XU Lili;SHE Ya’e;TENG Yiqun(Department of Pediatrics,Jiaxing Municipal Second Hospital,Jiaxing,Zhejiang 314001,China)

机构地区：[1]嘉兴市第二医院儿科,浙江嘉兴314001

出　　处：《重庆医学》2024年第23期3581-3584,共4页Chongqing Medical Journal

基　　金：浙江省嘉兴市科技计划项目(2021AD30086)。

摘　　要：目的探讨复方利多卡因乳膏不同给药时间对<3月龄婴儿腰椎穿刺术中的镇痛效果。方法选取2021年1月至2023年6月于该院儿科行腰椎穿刺的120例<3月龄婴儿为研究对象。根据随机数字表法分为对照组和观察一、二、三组,每组30例。对照组腰椎穿刺前穿刺局部无药物干预,观察一、二、三组分别于腰椎穿刺前10、30、60 min以穿刺点为中心涂抹复方利多卡因乳膏0.5 g、5 cm 2,比较4组腰椎穿刺穿刺前1 min、穿刺开始1 min、穿刺后3 min新生儿疼痛量表(NIPS)评分、心率、经皮血氧饱和度(SpO_(2))变化情况和穿刺成功率。结果与穿刺前1 min比较,穿刺开始1 min和穿刺后3 min 4组NIPS评分更高(P<0.05);穿刺开始1 min和穿刺后3 min观察一、二、三组NIPS评分低于对照组,且观察二、三组低于观察一组(P<0.05)。与穿刺前1 min比较,除穿刺后3 min观察三组心率更慢外,4组其余时刻心率更快(P<0.05);穿刺开始1 min和穿刺后3 min观察一、二、三组心率慢于对照组,且观察二、三组慢于观察一组(P<0.05)。4组SpO_(2)比较,差异无统计学意义(P>0.05)。观察一、二、三组穿刺成功率高于对照组(P<0.05)。结论在<3月龄婴儿腰椎穿刺术前30 min涂抹复方利多卡因乳膏具有良好镇痛效果,可提升穿刺成功率。Objective To investigate the analgesic effect of different administration times of compound lidocaine cream for lumbar paracentesis in the infants<3 months old Methods A total of 120 infants with lumbar puncture in the pediatric department of this hospital from January 2021 to June 2023 were selected as the study subjects and divided into the control group and observation 1,2,3 groups according to the random number table method,30 cases in each group.The control group had no medication intervention in the puncture local part before lumbar paracentesis,while the observation 1,2,3 groups were smeared the compound lidocaine cream 0.5 g,5 cm 2 with the puncture point as the center at 10,30,60 min before lumbar puncture.The change situation of the Neonatal Infant Pain Scale(NIPS)score,heart rate(HR)and transcutaneous blood oxygen saturation(SpO_(2))at 1 min before puncture,1 min of puncture beginning and 3 min after puncture and the puncture success rate were compared among 4 groups.Results Compared with at 1 min before puncture,the NIPS score at 1 min of puncture beginning and at 3 min after puncture in 4 group was higher,the NIPS score at 1 min of puncture beginning and at 3 min after puncture in the observation 1,2,3 groups was lower than that in the control group,moreover the observation 2,3 groups were lower the observation 1 group(P<0.05).Compared with at 1 min before puncture,except the heart rate at 3 min after puncture in the observation 3 group was slower,the heart rate at other time points in the 4 groups was faster(P<0.05);HR at 1 min of puncture beginning and at 3 min after puncture in the observation 1,2,3 groups was slower than that in the control group,moreover the observation 2,3 groups was lower than the observation 1 group(P<0.05),SpO_(2) had no statistical difference among 4 groups(P>0.05).The puncture success rate in the observation 1,2,3 groups was higher than that in the control group(P<0.05).Conclusion Smearing compound lidocaine cream before lumbar puncture in the infants<3 months old has a go

关 键 词：复方利多卡因乳膏 婴儿 腰椎穿刺术 疼痛 皮肤涂抹 

分 类 号：R726.1[医药卫生—儿科]