酒石酸泰万菌素纳米乳在肉鸡体内药代动力学研究  

Study on Pharmacokinetics of Tylvalosin Tartrate Nanoemulsion in Broilers

作　　者：杨一妍 刘畅 冯莉 李新国 王宏军 赵阳阳 孙晶鸣 鲍品桦 YANG Yi-yan;LIU Chang;FENG Li;LI Xin-guo;WANG Hong-jun;ZHAO Yang-yang;SUN Jing-ming;BAO Pin-hua(College of Animal Science and Veterinary Medicine,Jinzhou Medical University,Jinzhou,Liaoning,121001,China;Jinzhou Inspection and Testing Certification Center,Jinzhou,Liaoning,121000,China;Dengta Center for Animal Disease Control and Prevention,Dengta,Liaoning,111300,China;Zhongmu Industrial Co.,LTD.,Beijing,100070,China)

机构地区：[1]锦州医科大学畜牧兽医学院,辽宁锦州121001 [2]锦州市检验检测认证中心,辽宁锦州121000 [3]灯塔市动物疫病预防控制中心,辽宁灯塔111300 [4]中牧实业股份有限公司,北京100070

出　　处：《动物医学进展》2025年第1期87-90,共4页Progress In Veterinary Medicine

基　　金：辽宁省种质创新藏梁于技专项计划项目(2023JH1/10200006);辽宁省农村科技特派行动计划项目(2023JH5/10200005);锦州医科大学兽医高峰学科建设项目子课题(JY20238704和JY20238705)。

摘　　要：为了提高酒石酸泰万菌素(TAT)的生物利用度,制备了酒石酸泰万菌素纳米乳(TAT-NE)并进行其药代动力学研究。50日龄白羽肉鸡12只,设TAT可溶性粉(TAT-SP)和TAT-NE组,给2组每只鸡均单次灌服含TAT 20 mg/kg,于不同时间点翅下静脉采血,血浆经乙腈脱蛋白,HPLC检测血药浓度,DAS2.0版软件分析药代动力学参数。结果显示,鸡单次口服TAT-NE的AUC(0-t)为(672.329±3.634)(mg·h)/L显著高于TAT-SP(P<0.01),达峰时间T max分别为0.25 h、8 h,峰浓度C max分别为(125.601±2.056)mg/L、(48.398±4.387)mg/L,TAT-NE相对生物利用度为279.48%。由此表明,TAT-NE能够显著提高TAT的生物利用度。In order to improve the bioavailability of tylvalosin tartrate(TAT),tylvalosin tartrate nanoemulsion(TAT-NE)was prepared and its pharmacokinetics was studied.Twelve 50-day-old white feathered broilers were divided into TAT soluble powder(TAT-SP)group and TAT-NE group,and every broiler was single oral administration TAT 20 mg/(kg·BW).Blood was collected from subwing veins at different time points,plasma was deproteinized by acetonitrile,and blood drug concentration was detected by HPLC.Pharmacokinetic parameters were analyzed by DAS2.0 software.The results showed that area under curve[AUC(0-t)]of TAT-NE and TAT-SP were(672.329±3.634)(mg·h)/L and(240.561±97.541)(mg×h)/L,respectively,and the peak time(T max)were 0.25 h and 8h,respectively.The peak concentrations(C max)were(125.601±2.056)mg/L and(48.398±4.387)mg/L,respectively,and the relative bioavailability of TAT-NE was 279.48%.These conclusion indicated that TAT-NE could significantly improve the bioavailability of TAT.

关 键 词：酒石酸泰万菌素纳米乳 肉鸡 生物利用度 药代动力学 

分 类 号：S859.5[农业科学—临床兽医学]