微生物菌群调控人畜共患结核病的研究进展  

Advances in the Regulation of Zoonotic Tuberculosis by the Microbiota

作　　者：许霄峰 张广智 鑫婷[1,2] 叶建新 张建伟 贾丽 钱佳豪 温贺飞 吴慧光 蒋卉 丁家波 XU Xiao-feng;ZHANG Guang-zhi;XIN Ting;YE Jian-xin;ZHANG Jian-wei;JIA Li;QIAN Jia-hao;WEN He-fei;WU Hui-guang;JIANG Hui;DING Jia-bo(Beijing Institute of Animal Husbandry and Veterinary Medicine,Beijing,100097,China;Chinese Academy of Agricultural Sciences,Beijing,100093,China;College of Veterinary Medicine,Yangzhou University,Yangzhou,Zhejiang,225009,China;Beijing General Station of Animal Husbandry,Beijing,100193,China;Hebei Agricultural University College of Veternary Medicine,Baoding,Hebei,071000,China;Zunhua Municipal Bureau of Agriculture and Rural Affairs,Tangshan,Hebei,064200,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100097 [2]农业农村部动物生物安全风险预警及防控重点实验室(北方),北京100193 [3]扬州大学兽医学院,江苏扬州225009 [4]北京市畜牧总站,北京100193 [5]河北农业大学动物医学院,河北保定071000 [6]河北省遵化市农业农村局,河北唐山064200

出　　处：《动物医学进展》2025年第1期91-96,共6页Progress In Veterinary Medicine

基　　金：十四五国家重点研发计划项目(2022YFD1301105);中国农业科学院北京畜牧兽医研究所基本科研业务费项目(2022-YWF-ZYSQ-01);江苏省人兽共患病学重点实验室资助项目(R2211)。

摘　　要：目前,人畜共患结核病(zTB)仍是世界上最重要的细菌传染性疫病之一,严重威胁人和动物健康以及公共卫生安全。机体数量庞大的微生物菌群积极参与着机体的发育、免疫调控、代谢等。研究发现微生物菌群和zTB的发生、发展、治疗、疫苗免疫具有紧密的相关性,现已成为诸多领域中的研究热点。菌群对zTB进程的调控可通过诸多途径直接或间接地进行,如菌群稳态、代谢物及对免疫的调控等。基于此,论文综述了目前微生物菌群与zTB相关研究的最新进展,重点讨论了肠道菌群和肺部菌群与zTB的关联及调节机制,分析了肠-肺轴相互作用、菌群代谢产物对zTB的影响,探讨了通过调节宿主的菌群组成和功能对预防和辅助治疗结核病的潜在价值,旨在为zTB防控提供理论基础和借鉴。Zoonotic tuberculosis(zTB)is a significant bacterial infectious disease worldwide,posing a severe threat to human and animal health,as well as public health security.The body's microflora plays an active role in development,immune regulation,and metabolism.Research has shown that the microflora is closely linked to the occurrence,development,treatment,and vaccine immunity of zTB,making it a hot topic in many fields.The microbiota can regulate the zTB process directly or indirectly through various means,such as influencing microbiota homeostasis,metabolism,and immune regulation.The thesis reviews the latest research on microflora and zTB,focusing on the association and regulatory mechanisms of gut flora and lung flora with zTB infection.It analyses the influence of gut-lung axis crosstalk and microbiota metabolite on zTB and explores the potential value of regulating the host microbiota composition and functions in preventing and assisting in the treatment of zTB.The aim is to provide a theoretical basis and reference for the prevention and control of zTB.

关 键 词：人畜共患结核病 肠道微生物菌群 肠-肺轴 益生菌 

分 类 号：S855.2[农业科学—临床兽医学]