利伐沙班在犬和猫临床应用的研究进展  

Progress on the Clinical Applications of Rivaroxaban in Dogs and Cats

作　　者：王炜 江蓝 路心怡 付诗懿 刘亦婷 韦力煣 俞峰 刘波[1,2] WANG Wei;JIANG Lan;LU Xin-yi;FU Shi-yi;LIU Yi-ting;WEI Li-rou;YU Feng;LIU Bo(College of Veterinary Medicine,China Agricultural University,Beijing,100193,China;Veterinary Teaching Hospital of China Agricultural University,Beijing,100193,China)

机构地区：[1]中国农业大学动物医学院,北京100193 [2]中国农业大学教学动物医院,北京100193

出　　处：《动物医学进展》2025年第1期97-102,共6页Progress In Veterinary Medicine

摘　　要：血栓栓塞是犬、猫临床上多种疾病的并发症,可累及动脉或静脉,预后较差。目前兽医临床防治血栓栓塞可用的抗血栓药物种类有限,影响临床诊疗水平,引入新药具有实际意义。利伐沙班是一种新型非维生素K拮抗剂类口服抗凝药物,研究证明其能够特异性抑制活性凝血因子X从而抑制血栓形成。近年来人医领域对利伐沙班的相关临床研究逐渐丰富,涉及单用利伐沙班或使用双通路抑制疗法防治不同类型的动、静脉血栓栓塞,可为其应用于兽医临床提供据。犬、猫临床使用利伐沙班的研究正相继开展,论文就犬、猫血栓栓塞疾病发病情况、防治现状,利伐沙班的药理学特性及其在人医、兽医领域的临床试验研究进展进行综述,以期为兽医临床上利伐沙班的进一步研究提供参考。Thromboembolism constitutes a common complication of various diseases in dogs and cats,impacting either arteries or veins and generally associated with a poor prognosis.The range of antithrombotic drugs currently available for veterinary clinical prevention and treatment of thromboembolism is limited,which affects the level of clinical diagnosis and treatment.The introduction of new drugs in this field is of practical significance.Rivaroxaban,a novel non-vitamin K-dependent antagonist oral anticoagulant,has been proven to specifically inhibit the activity of coagulation factor X,thereby preventing thrombus formation.Recent years have seen a growing body of clinical research on rivaroxaban in human medicine,involving its sole use or in combination with dual-pathway inhibition therapy for the prevention and treatment of various types of arterial and venous thromboembolisms.This expanding research provides a solid basis for its application in veterinary medicine.Studies on the use of rivaroxaban in dogs and cats are progressively being undertaken.This paper provides an overview of the incidence and current state of prevention and treatment of thromboembolic diseases in dogs and cats,the pharmacological characteristics of rivaroxaban,and its clinical trial progress in both human and veterinary medicine.The aim is to furnish a reference for further research on the use of rivaroxaban in veterinary clinical practice.

关 键 词：新型口服抗凝药 利伐沙班 血栓栓塞 犬 猫 

分 类 号：S859.7[农业科学—临床兽医学]