解肌颗粒治疗小儿外感发热临床研究  

Jieji Granule in the Treatment of Exogenous Fever in Children

作　　者：温旭 李金云 WEN Xu;LI Jinyun(Department of Traditional Chinese Medicine,Jinxiang Maternal and Child Health and Family Planning Service Center,Shandong Province,Jining 272200,China;Department of Pediatrics,Jinxiang Maternal and Child Health and Family Planning Service Center,Shandong Province,Jining 272200,China)

机构地区：[1]山东省金乡县妇幼保健计划生育服务中心中医科,山东济宁272200 [2]山东省金乡县妇幼保健计划生育服务中心儿科,山东济宁272200

出　　处：《中国中医药现代远程教育》2024年第24期141-144,共4页Chinese Medicine Modern Distance Education of China

基　　金：中国妇幼保健协会-华润三九专项研究基金[No.ZXY2020B11]。

摘　　要：目的观察解肌颗粒治疗小儿外感发热的临床效果。方法将120例外感发热患儿,随机分为中药颗粒组、中西医治疗组、西药组,每组40例。中药颗粒组给予解肌颗粒口服,西药组给予重组人干扰素α2b喷雾剂雾化吸入,中西医治疗组给予解肌颗粒口服联合重组人干扰素α2b喷雾剂雾化吸入。观察三组退热起效时间、完全退热时间以及中医证候综合疗效积分、治疗总有效率。结果中西医治疗组和中药颗粒组总有效率均为97.5%(39/40),差异无统计学意义(P>0.05),但皆优于西药组的85.0%(34/40)(P<0.05)。中西医治疗组患儿退热起效时间、完全退热时间最短,中药颗粒组次之,西药组最长(P<0.05)。治疗后,中西医治疗组中医证候综合疗效积分最低,中药颗粒组略高,西药组最高(P<0.05)。结论采用解肌颗粒治疗小儿外感发热,临床效果确切且优于单独应用重组人干扰素α2b喷雾剂,可有效改善患儿临床症状,安全性高;联合应用重组人干扰素α2b喷雾剂,可缩短治疗时间。Objective To observe the clinical efficacy of Jieji granule in the treatment exogenous fever in children.Methods A total of 120 children with exogenous fever were randomly divided into Chinese medicine granule group,integrated medicine group and West⁃ern medicine group,with 40 cases in each group.The Chinese medicine granule group was given Jieji granule by mouth,the Western medicine group was given recombinant human interferonα2b aerosol inhalation,and the integrated medicine group was given Jieji granule combined with recombinant human interferonα2b aerosol inhalation.The time of onset of fever,the time of complete fever,the integrative efficacy of TCM syndromes and the total effective rate of treatment were observed.Results The total effective rate of inte⁃grated medicine group and Chinese medicine granule group was 97.5%(39/40),and the difference was not statistical significance(P>0.05),but both were better than 85.0%(34/40)in Western medicine group(P<0.05).The onset time and complete febrile regression time of children in integrated medicine group were the shortest,followed by Chinese medicine granule group,and Western medicine group was the longest(P<0.05).After treatment,the comprehensive efficacy scores of TCM syndromes in the integrated medicine treat⁃ment group were the lowest,the Chinese medicine granule group was slightly higher,and the Western medicine group was the highest(P<0.05).Conclusion Jieji granule is clinically effective in treating exogenous fever in children and is superior to recombinant human interferonα2b spray alone,which can effectively improve the clinical symptoms of children with high safety.Combined application of recombinant human interferonα2b spray can shorten the treatment time.

关 键 词：外感发热 解肌颗粒 儿科学 中成药疗法 

分 类 号：R272[医药卫生—中医儿科学]