Recent progress in stimuli-responsive DNA-based logic gates:Design,working principles and biological applications  

作　　者：Ling Sum Liu Hoi Man Leung Yuzhen Cai Pik Kwan Lo 

机构地区：[1]Department of Chemistry and State Key Laboratory of Marine Pollution,City University of Hong Kong,Kowloon Tong,Hong Kong SAR,China [2]Department of Chemistry,Molecular Sciences Research Hub,Imperial College London,White City Campus,London,UK [3]Key Laboratory of Biochip Technology,Biotech and Health Care,Shenzhen Research Institute of City University of Hong Kong,Shenzhen,China

出　　处：《Smart Molecules》2024年第1期25-43,共19页智能分子（英文）

基　　金：supported by Hong Kong Research Grants Council(11307421,11301220,and 11304719);Health and Medical Research Fund(09203576 and 07181396);National Science Foundation of China(21574109 and 217780430);The Science and Technology Innovation Committee of Shenzhen Municipality(JCYJ20190812160203619);City University of Hong Kong 7005832 and 7006006.

摘　　要：Stimuli-responsive DNA-based logic gates have emerged as a promising field at the intersection of synthetic biology and nanotechnology.These gates exploit the unique properties of DNA molecules to perform programmable computational operations in response to specific stimuli.This review provides a comprehensive overview of recent advancements in the design,working principles,and applications of stimuli-responsive DNA-based logic gates.The progress made in developing various types of logic gates triggered by metal ions,pH,oligonucleotides,small molecules,proteins,and light is highlighted.The applications of these logic gates in imaging and biosensing,drug delivery,synthetic biology and molecular computing are discussed.This review underscores the significant contributions and future prospects of stimuli-responsive DNA-based logic gates in advancing the field of nanotechnology.

关 键 词：DNA logic gates drug delivery IMAGING molecular computation STIMULI-RESPONSIVE 

分 类 号：TN7[电子电信—电路与系统]