Effect of aerobic intermittent exercise on the decreased cognitive ability induced by PM_(2.5)exposure in rats  

作　　者：Zhongwei Wang Fei Qin Dongzhe Wu Minxiao Xu Shuqiang Cui Jiexiu Zhao 

机构地区：[1]Exercise Biological Center,China Institute of Sport Science,Beijing,China,100061 [2]School of Physical Education,Jinan University,Guangzhou,China [3]Institute of Physical Education and Training,Capital University of Physical Education and Sports,Beijing,China [4]Athletic Sports Research Lab,Beijing Institute of Sports Science,Beijing,China

出　　处：《Translational Exercise Biomedicine》2024年第2期170-181,共12页运动转化生物医学（英文）

摘　　要：Objectives:This study aimed to investigate the protective effects and underlying mechanisms of aerobic intermittent exercise on cognitive impairment by PM_(2.5)exposure.Methods:Thirty-two rats were randomly divided into four groups:sedentary,exercise,sedentary+PM_(2.5)exposure,and exercise+PM_(2.5)exposure.The exercise groups underwent 8 weeks of exercise training(5 days of exercise per week).Subsequently,PM_(2.5)exposure groups were subjected to PM_(2.5)for three weeks.Post-exposure,we assessed cognitive abilities(shuttle box test),hippocampal tissue structure,related inflammatory factors(TNF-α,IL-6,IL-1β),the protein of inflammatory responses mechanism(P65,IκκB)and cognitiverelated protein levels(BDNF,Aβ-42).Results:PM_(2.5)exposure caused cognitive impairment,abnormal histopathological changes,reduced cognitive related protein and increased pro-inflammatory cytokine levels.Analysis of shuttle box test data revealed significant main effects on the passive avoidance latency times measured in rats(p<0.05).Aerobic intermittent exercise improves spatial learning decline in rats induced by PM_(2.5).Conversely,the Exercise+PM_(2.5)group demonstrated a significant reduction in latency of 24.9%compared to the Sedentary+PM_(2.5)group(p<0.05,ES=1.41).Conclustion:Aerobic intermittent exercise may help in protecting against the decrease of cognitive ability induced by PM_(2.5)exposure.

关 键 词：aerobic interval exercise particle matters cognitive behavior abilities NFκB signal pathway 

分 类 号：R28[医药卫生—中药学]