Selectivin:A nematicide from parasitic nematodes-specifically activated chemical  

作　　者：En-Yu Jiang Otgonpurev Sukhbaatar Ming-Zhi Zhang Wei-Hua Zhang Yu-Cheng Gu 

机构地区：[1]Jiangsu Key Laboratory of Pesticide Science,College of Sciences,Nanjing Agricultural University,Nanjing 210095,China [2]Department of Chemistry,School of Applied Sciences,Mongolian University of Life Sciences,Mongolia [3]Syngenta,Jealott's Hill International Research Centre,Bracknell,Berkshire RG426EY,United Kingdom

出　　处：《Advanced Agrochem》2024年第2期111-114,共4页现代农业化学（英文）

基　　金：supported in part by the National Key Research and Development Program of China(2021YFD1700103);the National Natural Science Foundation of China(22177051,32061143045);the Fundamental Research Funds for the Central Universities(KYCYXT2022010);Sichuan Key Research and Development Program(22ZDYF0186,2021YFN0134).

摘　　要：The latest study published in Nature by Andrew R.Burns,Peter J.Roy and co-authors is highlighted in this paper,they investigated a series of novel nematicidal compounds,including Selectivin-A and Selectivin-E,and explored their mechanism of action.Experiments have displayed that the Selectivin compound is inactive to human cells,fish,fungi,insects and even beneficial nematodes.In the exploration of its mechanism of action,it was found that the mechanism of action of Selectivin is different with those of commercial nematocides:Selectivin needs to be activated by biotin produced by nematodes,after that they can be transformed into compounds with high nematicidal activity.This proves that the family of Selectivin compounds has the advantages of high selectivity and environmental friendliness,and their mechanism of action is completely new,proposing a completely new path for the development of new nematicides.

关 键 词：Plant-parasitic nematodes(PPNs) Nematode control CYPS Emb-8 CYP4731A3 

分 类 号：O62[理学—有机化学]