Practical method for the large-scale synthesis of 4′-chloro-2-nitrobiphenyl:A key intermediate of Boscalid  

作　　者：You Chen Tong Meng Rui Guo Zhaoru Liu Sixuan Meng Jian Chen Guang-Ao Yu 

机构地区：[1]National Key Laboratory of Green Pesticide,Key Laboratory of Pesticide&Chemical Biology of Ministry of Education,International Joint Research Center for Intelligent Biosensor Technology and Health,College of Chemistry,Central China Normal University,Wuhan,430079,PR China [2]Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances,School of Environment and Health,Jianghan University,Wuhan,430056,PR China

出　　处：《Advanced Agrochem》2024年第3期256-260,共5页现代农业化学（英文）

基　　金：the National Natural Science Foundation of China(nos.22371084,21072071,21472060 and 21772058);the 111 Project B17019,self-determined research funds of CCNU from the colleges'basic research and operation of MOE(No.CCNU17CG0011,CCNU17KYZHSY07,and CCNU18KYZHSY06)for financial support.

摘　　要：Boscalid is a pesticide with the advantages of broad spectrum bactericidal activity,high efficiency,low toxicity,and no cross-resistance with other fungicides currently available on the market.Herein,we report the synthesis of 40-chloro-2-nitrobiphenyl,a key intermediate of Boscalid using a palladium-catalyzed Suzuki-Miyaura cross-coupling employing the 2-aryl-substituted indenyl phosphine ligand.40-Chloro-2-nitrobiphenyl was prepared in 94%yield on a 100 g scale.This method allows for the industrial production of alimide and active substances bearing a biphenyl moiety.

关 键 词：BOS SYNTHESIS INTERMEDIATE 

分 类 号：S48[农业科学—农药学]