Design,synthesis and biological evaluation of thiazole and imidazo[1,2-a]pyridine derivatives containing a hydrazone substructure as potential agrochemicals  

作　　者：Xiaofang Yao Rongrong Zhang Bo Lv Wei-Wei Wang Zhigang Liu Zhaonong Hu Ding Li 

机构地区：[1]Shaanxi Key Laboratory of Natural Products&Chemical Biology,College of Chemistry&Pharmacy,Northwest A&F University,Yangling,712100,China [2]College of Plant Protection,Northwest A&F University,Yangling,Shaanxi,712100,China [3]Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau,Ministry of Agriculture,Yangling,Shaanxi,712100,China

出　　处：《Advanced Agrochem》2023年第2期154-162,共9页现代农业化学（英文）

基　　金：supported by the National Natural Science Foundation of China(31972303);the Natural Science Basic Research Program of Shaanxi Province(Program No.2023-JC-YB-144,2023-JC-YB-719).

摘　　要：Agricultural chemicals with multifunctional applications in crop protection have attracted increasing attention.Herein,two new series of thiazole and imidazo[1,2-a]pyridine derivatives containing a hydrazone substructure were designed and synthesized via a concise synthesis route.Bioassay results showed that most of the thiazole derivatives exhibited broad-spectrum fungistatic activities,which were exemplified by compounds 1c,1e,1g,1h and 1j.In particular,compound 1e displayed excellent in vitro inhibitory effects with the EC50 values of 5.00,18.24,6.94,and 3.03μg/mL against the fungi Botrytis cinerea,Cytospora sp,Fusarium graminearum,and Fusarium solani,respectively.Detached fruit experiments against tomato gray mold(caused by B.cinerea)in vivo revealed that the control efficiency of compound 1e at 10,20 and 40μg/mL for 5 days was 35.05%,54.14%and 81.83%,respectively,which was comparable and even superior to that of the fungicide carbendazim.Additionally,the title compounds also showed remarkable larvicidal activity against M.separata and some compounds exhibited good aphicidal activity.In a word,the bioassay indicated that a certain number of title compounds had multiple biological activities.Given their excellent antifungal and larvicidal characteristics,these interesting derivatives based on the title compounds could be served as new scaffolds for the development of pesticide with multifunctional applications.

关 键 词：THIAZOLE imidazo[1 2-a]pyridine Hydrazone Antifungal activity Insecticidal activity 

分 类 号：O62[理学—有机化学]