Functional nucleic acids with synthetic sugar or nucleobase moieties  

作　　者：Ze Zhang Siqi Chen Zhe Li Hanyang Yu 

机构地区：[1]State Key Laboratory of Coordination Chemistry,Department of Biomedical Engineering,College of Engineering and Applied Sciences,Chemistry and Biomedicine Innovation Center(ChemBIC),Jiangsu Key Laboratory of Artificial Functional Materials,Nanjing University,Nanjing,Jiangsu,210023,China [2]State Key Laboratory of Analytical Chemistry for Life Science,Department of Biomedical Engineering,College of Engineering and Applied Sciences,Nanjing University,Nanjing,210023,China

出　　处：《Advanced Agrochem》2023年第3期236-245,共10页现代农业化学（英文）

基　　金：the National Key Research and Development Program of China(2019YFA0904000 and 2021YFF1200203);the National Natural Science Foundation of China(21977046 and 22277049);the Fundamental Research Funds for the Central Universities(0213–14380192);the Program for Innovative Talents and Entrepreneur in Jiangsu is gratefully acknowledged.

摘　　要：Functional nucleic acids including aptamers and DNAzymes are a class of valuable molecular tool for biotechnology.However,DNA and RNA aptamers and catalysts suffer from low biological stability and limited chemical diversity.Xeno-nucleic acids(XNAs)refer to nucleic acid analogues containing sugar moieties that are structurally distinct from DNA and RNA and possess advantageous properties.In this article,we first focus on two types of XNAs,threose nucleic acid(TNA)and 2’-fluoroarabinose nucleic acid(FANA),and summarize recent in vitro selections of TNA and FANA aptamers and catalysts.We then review three classes of unnatural base pairs(UBPs)and highlight examples of UBP-containing DNA aptamers and DNAzymes.Lastly,we briefly describe an XNA-modified DNAzyme 10–23(X10-23)and its application in RNA knockdown and virus detection.Functional XNAs provide important chemical biology tools for biomedical research and future interdisciplinary collaboration will boost XNA basic research and clinical translation.

关 键 词：properties. SUGAR BASE 

分 类 号：O62[理学—有机化学]