Recent advances in the natural products-based lead discovery for new agrochemicals  

作　　者：Pei Zhang Chun-Bao Duan Bing Jin Abdallah S.Ali Xinya Han Haifeng Zhang Ming-Zhi Zhang Wei-Hua Zhang Yu-Cheng Gu 

机构地区：[1]Jiangsu Key Laboratory of Pesticide Science,College of Sciences,Nanjing Agricultural Univer-sity,Nanjing,210095,China [2]Department of Microbiology,Faculty of Agriculture,Cairo University,12613,Giza,Egypt [3]School of Chemistry&Chemical Engineering,Anhui University of Technology,Ma'anshan,243002,China [4]Department of Plant Pathology,College of Plant Protection,Nanjing Agricultural University,Nanjing,210095,China [5]Syngenta,Jealott's Hill International Research Centre,Bracknell,Berkshire,RG426EY,United Kingdom

出　　处：《Advanced Agrochem》2023年第4期324-339,共16页现代农业化学（英文）

基　　金：the financial support for this research from the National Natural Science Foundation of China(22177051,32061143045);the National Key Research and Development Program of China(2021YFD1700103);Sichuan Key Research and Development Program(22ZDYF0186,2021YFN0134);the College Student Research Training Program from Nanjing Agricultural University(202110307002T).

摘　　要：Crops will be harmed by fungi,pests and weeds during their growth.In the past half century,scientists have conducted in-depth research on natural products extracted from microorganisms,plants or animals,and used natural products and their derivatives as the lead for pesticides discovery.Natural product pesticides have the advantages of easy degradation in the environment,selective control and safety to non-target organisms.This review summarizes the studies on natural products pesticides in recent years,including natural products of chemical modification and biosynthesis,mainly fungicides,herbicides,insecticides and acaricides.We classify natural products according to their active fragments,and discuss their effects on the control of agricultural fungi,pests and weeds.Ultimately,we found that lead discovery based on natural products has great advantages in pesticide development.

关 键 词：Natural products Lead discovery FUNGICIDE INSECTICIDE HERBICIDE 

分 类 号：F42[经济管理—产业经济]