1990—2019年归因于代谢因素的糖尿病疾病负担分析  

Analysis of the burden of diabetes attributed to metabolic factors from 1990 to 2019

作　　者：唐桢 谢玉瑾 郭新响 刘慧娟 关锐 朱峰 李海静 肖中男 仲玉[1] TANG Zhen;XIE Yujin;GUO Xinxiang;LIU Huijuan;GUAN Rui;ZHU Feng;LI Haijing;XIAO Zhongnan;ZHONG Yu(Beijing Rehabilitation Hospital,Capital Medical University,Beijing 100144,China)

机构地区：[1]首都医科大学附属北京康复医院健康管理中心,北京100144

出　　处：《上海预防医学》2024年第10期991-996,共6页Shanghai Journal of Preventive Medicine

摘　　要：【目的】分析1990—2019年我国归因于代谢因素的糖尿病疾病负担的长期趋势,为我国糖尿病防控提供科学依据。【方法】从全球疾病负担(GBD)2019获取1990—2019年中国归因于代谢因素的糖尿病死亡、伤残调整生命年(DALY)、伤残所致寿命损失年(YLD)、早死所致寿命损失年(YLL)等数据,并进行描述性分析。运用Joinpoint回归模型分析死亡率和DALY率的长期变化趋势,并分析高空腹血糖(FPG)、高体重指数(BMI)2个代谢危险因素对糖尿病疾病负担的影响。【结果】1990—2019年中国总人群归因于代谢因素的糖尿病标化死亡率和标化DALY率整体呈上升趋势,平均年度变化百分比(AAPC)均为总人口的0.1%。其中,男性呈上升趋势,AAPC分别为0.9%和0.6%;女性呈下降趋势,AAPC分别为−0.4%和−0.3%。随着年龄的增加,归因于代谢因素的糖尿病疾病负担均呈上升趋势,2个归因风险因素的影响顺位分别是高FPG和高BMI,我国男性归因于代谢因素糖尿病的疾病负担高于女性。【结论】我国总人口、男性归因于代谢因素的糖尿病疾病负担呈上升趋势,女性呈下降趋势。需要加强≥65岁男性人群干预,科学指导居民饮食及生活习惯,控制血糖及体重。[Objective]To analyze the long-term trends of the disease burden of diabetes attributed to metabolic factors in China from 1990 to 2019,and provide scientific recommendations for diabetes prevention and control in China.[Methods]Descriptive analysis was conducted on the disease burden data of diabetes attributed to metabolic factors in China from 1990 to 2019,obtained from GBD 2019,encompassing death form diabetes,disability-adjusted life years(DALY),years of life lost(YLL),and years lived with disability(YLD).Joinpoint regression models were employed to analyze the long-term trends in mortality and DALY rates.Furthermore,the study examined the impact of two metabolic risk factors,high fasting plasma glucose(FPG)levels and high body mass index(BMI)levels,on the disease burden of diabetes.[Results]From 1990 to 2019,the overall standardized mortality and DALY rates attributed to metabolic factors for diabetes in the general population in China showed an upward trend,with both average annual percent changes(AAPCs)of 0.1%in the total population.The trend was upward in males with AAPCs of 0.9%and 0.6%,while it was downward in females with AAPCs of-0.4%and-0.3%.As age increased,the disease burden of diabetes attributed to metabolic factors showed an upward trend,with high FPG and high BMI ranking as the top two attributing risk factors.The disease burden of diabetes attributed to metabolic factors was higher in Chinese males than females.[Conclusion]The disease burden of diabetes attributed to metabolic factors is increasing among the overall population and particularly among males,while the burden for female is declining.There is a need to increase intervention efforts for males aged 65 and above,provide scientific guidance on residents’diet and lifestyle habits,and control blood glucose and body weight.

关 键 词：糖尿病 代谢因素 疾病负担 Joinpoint回归模型 

分 类 号：R1[医药卫生—公共卫生与预防医学] R58