航天环境调节肠道菌群及其代谢产物的研究进展  

Research advances in regulation of intestinal flora and its metabolites by space environment

作　　者：王艺璇 柴欣 王宏丽 洪金鹏 王彪猛 陈嘉屿 WANG Yixuan;CHAI Xin;WANG Hongli;HONG Jinpeng;WANG Biaomeng;CHEN Jiayu(Department of Gastroenterology,the 940th Hospital of Joint Logistics Support Force of Chinese PLA,Lanzhou 730050,Gansu Province,China;Department of Infectious Disease,the 940th Hospital of Joint Logistics Support Force of Chinese PLA,Lanzhou 730050,Gansu Province,China)

机构地区：[1]解放军联勤保障部队第940医院消化内科,甘肃兰州730050 [2]解放军联勤保障部队第940医院感染科,甘肃兰州730050

出　　处：《解放军医学院学报》2024年第9期1000-1005,共6页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金青年基金项目(82302112);甘肃省青年科技基金项目(23JRRA320)。

摘　　要：肠道菌群是人体肠道微环境的重要组成部分,可与宿主的免疫、代谢和神经系统等相互作用,是人体多个生理及病理过程的基本决定因素。肠道菌群代谢产物是肠道菌群调节机体稳态的重要环节,包括肠道细菌分解膳食成分产生的代谢物、宿主产生并经肠道细菌修饰的代谢物及肠道细菌从头合成的代谢物。航天飞行中微重力、辐射、饮食改变等均会影响肠道菌群的构成及代谢途径,促使肠道菌群种类发生改变、厚壁杆菌/拟杆菌比例失调、有益代谢产物减少而有害代谢产物增加等,诱发机体免疫、心血管、肌骨等多系统功能紊乱,进而影响机体生理健康。本文概述了航天环境调节肠道菌群及其代谢产物的研究进展。Intestinal flora is an important part of the human intestinal microenvironment,which can interact with the immune,metabolic and nervous systems,and is the basic determinant of multiple physiological and pathological processes of the human body.Gut microbiota metabolites are important links for gut microbiota to regulate body homeostasis,including metabolites produced by gut bacteria decomposing dietary components,metabolites produced by the host and modified by gut bacteria,and metabolites synthesized de novo by gut bacteria.Microgravity,radiation and dietary changes during space flight have a significant impact on the composition and metabolic pathway of intestinal flora,promote the change of intestinal flora,the imbalance of the proportion of Firmicum/Bacteroides,the decrease of beneficial metabolites and the increase of harmful metabolites,and induce the dysfunction of immune,cardiovascular,muscle and bone systems,thus affecting the physiological health of the body.Recent research advances in regulation of intestinal flora and its metabolites by space environment are reviewed in this paper.

关 键 词：航天环境 肠道菌群 短链脂肪酸 微重力 辐射 

分 类 号：R33[医药卫生—人体生理学]