Hirschsprung-associated enterocolitis:a comprehensive review  

作　　者：Ioannis A Ziogas Korah P Kuruvilla Ming Fu Ankush Gosain 

机构地区：[1]Division of Pediatric Surgery,Department of Surgery,Children's Hospital Colorado,Aurora,Colorado,USA

出　　处：《World Journal of Pediatric Surgery》2024年第3期173-180,共8页世界小儿外科杂志（英文）

基　　金：supported by grants from the National Institutes of Health,USA(R01DK125047 to AG,R21Al163503 to AG).

摘　　要：Hirschsprung-associated enterocolitis(HAEC)is an important cause of morbidity and the leading cause of mortality in patients with Hirschsprung disease.The pathophysiology of disease includes dysmotility of the enteric nervous system,dysbiosis of the microbiota,failure of the intestinal barrier,and impaired immunity.Common manifestations include fever,abdominal distension,lethargy,vomiting,and diarrhea.Given the non-specific signs and symptoms of HAEC,high clinical suspicion is warranted,especially in patients with risk factors.Diagnosis and management of HAEC depend on the severity of disease presentation.Several preoperative and postoperative modalities have been explored to prevent HAEC.The current review elaborates on the risk factors,pathogenesis,diagnosis,treatment,and prevention of HAEC.

关 键 词：PREVENTION diagnosis DIARRHEA 

分 类 号：R726.5[医药卫生—儿科]