骨质疏松性椎体压缩骨折患者的临床调查分析  

Clinical Investigation and Analysis of Osteoporotic Vertebral Compression Fractures

作　　者：龙思萍 熊绪[1,3] 万文 钟彦鑫 陈江伟 周荣平[1,3] 黄山虎 刘志礼[1,3] 刘家明 杜浏学[1,3] LONG Si-ping;XIONG Xu;WAN Wen;ZHONG Yan-xin;CHEN Jiang-wei;ZHOU Rong-ping;HUANG Shan-hu;LIU Zhi-li;LIU Jia-ming;DU Liu-xue(Department of Orthopaedic Surgery,the First Affiliated Hospital,Nanchang University;College of Rehabilitation Medicine,Nanchang University;Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease,Nanchang 330006,China)

机构地区：[1]南昌大学第一附属医院骨科 [2]南昌大学康复学院 [3]脊柱脊髓系统疾病江西省重点实验室,南昌330006

出　　处：《南昌大学学报（医学版）》2024年第6期73-79,共7页Journal of Nanchang University：Medical Sciences

基　　金：江西省重点研发计划(20223BBG71S02);中央引导地方科技发展资金(20222ZDH04095)。

摘　　要：目的探讨骨质疏松性椎体压缩骨折(OVCF)的流行病学及临床特征,并分析OVCF再骨折的影响因素。方法收集我南昌大学第一附属医院2022年收治的OVCF患者的临床资料,回顾性分析其流行病学和临床特征。根据是否发生再骨折将患者分为初次骨折组和再骨折组,比较2组间性别、年龄、体重指数(BMI)和各项实验室检查指标,分析OVCF患者再骨折的影响因素。结果共纳入675例OVCF患者,其中男117例(17.3%),女558例(82.7%),男女比例为1∶4.77;年龄50~96岁,男性好发于70~89岁,女性好发于60~79岁;超体重患者占比(23.1%)为低体重患者(11.1%)的2.1倍。675例OVCF共累及929个椎体,以单个椎体发病最为常见,骨折椎体部位多见于胸腰段(T11—L2)。初次骨折患者589例,再骨折患者86例,再骨折发生的比率为12.7%。与初次骨折组比较,再骨折组的平均年龄和超体重者占比明显较高(P<0.05和P<0.01),而骨钙素水平明显较低(P<0.01)。结论OVCF女性发病多于男性,累及胸腰段(T11—L2)最常见,超体重患者更易发生OVCF。高年龄、超体重和骨钙素水平低是OVCF再骨折的危险因素。Objective To investigate the epidemiological and clinical characteristics of osteoporotic vertebral compression fractures(OVCF)and analyze the influencing factors of OVCF refracture.Methods The clinical data of OVCF patients admitted to the First Affiliated Hospital of Nanchang University in 2022 were collected,and a retrospective analysis was conducted on their epidemiological and clinical characteristics.Patients were divided into the primary fracture group and the refracture group based on whether refracture occurred.The differences of gender,age,BMI and various laboratory indicators between the 2 groups were compared to analyze the influencing factors of refractures in OVCF patients.Results A total of 675 OVCF patients were included,with 117 males(17.3%)and 558 females(82.7%),resulting in a male-to-female ratio of 1∶4.77.The age range was from 50 to 96 years,with a higher prevalence among males aged 70 to 89 years and females aged 60 to 79 years.The proportion of overweight patients(23.1%)was 2.1 times higher than that of underweight patients(11.1%).Among the 675 OVCF cases,929 vertebral bodies were affected,of which a single vertebral body was the most common,and the location of fractured vertebrae was most common in the thoracolumbar region(T11-L2).There were 589 patients with primary fracture and 86 patients with refracture,and the incidence of refracture was 12.7%.Compared to the primary fracture group,the refracture group had significantly higher average age and proportion of overweight patients(P<0.05 and P<0.01,respectively),while the level of osteocalcin was significantly lower(P<0.01).Conclusion The findings suggest that the incidence of OVCF is higher among females compared to males,with the thoracolumbar segment(T11-L2)being the most commonly affected area,and overweight patients are more susceptible to OVCF.Advanced age,overweight,and low osteocalcin levels are identified as potential risk factors for refracture in OVCF patients.

关 键 词：骨质疏松性椎体压缩骨折 再骨折 流行病学 临床特征 

分 类 号：R683.2[医药卫生—骨科学]