机构地区:[1]濮阳市人民医院急诊科,河南濮阳457000 [2]濮阳油田总医院心内科,河南濮阳457001
出 处:《实用心电学杂志》2024年第6期617-620,共4页Journal of Practical Electrocardiology
摘 要:目的探讨8-羟基脱氧鸟苷(8-hydroxy-2′-deoxyguanosine,8-OHdG)、NT-proBNP、锰超氧化物歧化酶(manganese superoxide dismutase,MnSOD)在心力衰竭(简称心衰)患者血清中的变化及其与认知功能的相关性。方法前瞻性选取96例心衰患者作为研究对象(心衰组),另选取同期健康体检者96例作为对照组。通过蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)评分评估心衰患者认知功能。对比两组及不同认知功能状态患者入院时血清8-OHdG、NT-proBNP、MnSOD水平,并分析上述三项血清指标与MoCA评分的相关性。分析入院时上述三项血清指标对心衰患者认知功能障碍的诊断价值。结果心衰组患者入院时血清8-OHdG、NT-proBNP水平显著高于对照组,血清MnSOD水平显著低于对照组(均P<0.01)。存在认知功能障碍的心衰患者血清8-OHdG、NT-proBNP水平显著高于认知功能正常患者,血清MnSOD水平显著低于认知功能正常患者(均P<0.01)。心衰患者入院时血清8-OHdG、NT-proBNP水平与MoCA评分均呈正相关,血清MnSOD水平与MoCA评分呈负相关(均P<0.05)。入院时血清8-OHdG、NT-proBNP、MnSOD水平联合诊断心衰患者认知功能障碍的曲线下面积、敏感性以及特异性均明显高于三项指标分别单独应用时。结论血清8-OHdG、NT-proBNP、MnSOD水平与心衰患者并发认知功能障碍密切相关,三者联合检测对心衰患者发生认知功能障碍的诊断价值明显增加,可为临床治疗提供参考。Objective To investigate the changes of serum 8-hydroxy-2′-deoxyguanosine(8-OHdG),NT-proBNP and manganese superoxide dismutase(MnSOD) in patients with heart failure(HF),and their correlation with cognitive function.Methods Ninety-six patients with HF were prospectively selected as reserach objects(HF group),meanwhile,another 96 healthy physical examinees were also enrolled as the control group.The cognitive function of the HF patients was assessed by the Montreal cognitive assessment(MoCA) score.The serum levels of 8-OHdG,NT-proBNP and MnSOD were compared between the two groups,and patients with different cognitive status at admission.The correlation between the levels of the above three serum markers and MoCA score was also analyzed.The diagnostic value of the above three serum indicators for cognitive dysfunction at admission was analyzed.Results The levels of serum 8-OHdG and NT-proBNP in patients with HF at admission were significantly higher than those in the control group,while the level of serum MnSOD was significantly lower(all P<0.01).The levels of serum 8-OHdG and NT-proBNP in HF patients with cognitive dysfunction were significantly higher than those in HF patients with normal cognition funtion,while the level of serum MnSOD was significantly lower(all P<0.01).For the HF patients at admission,the levels of serum 8-OHdG and NT-proBNP were both positively correlated with the MoCA score,while the level of serum MnSOD was negatively correlated with the MoCA score(all P<0.05).In the diagnosis of cognitive dysfunction among HF patients,the area under the curve,sensitivity,and specificity of the combination of serum 8-OHdG,NT-proBNP,and MnSOD levels at admission were all significantly higher than those by using any single of the three indicators.Conclusion The serum levels of 8-OHdG,NT-proBNP and MnSOD are closely related to complicated cognitive dysfunction in patients with HF.The joint detection of the three markers significantly increases the diagnostic value of cognitive dysfunction in HF patients,which
关 键 词:8-羟基脱氧鸟苷 NT-PROBNP 锰超氧化物歧化酶 心力衰竭 认知功能
分 类 号:R541.6[医药卫生—心血管疾病]
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