蛋白质基防生物污染涂层研究进展  

Research Progress on Protein-based Anti-biofouling Coatings

作　　者：王雪霆 晋晓倩 葛婉仪 刘丽媛 邓旭东 尹大川 WANG Xueting;JIN Xiaoqian;GE Wanyi;LIU Liyuan;DENG Xudong;YIN Dachuan(Key Laboratory for Space Bioscience and Biotechnology,School of Life Sciences,Northwestern Polytechnical University,Xi'an 710129,China)

机构地区：[1]西北工业大学生命学院空间生物实验模拟技术重点实验室,西安710129

出　　处：《表面技术》2024年第23期31-45,110,共16页Surface Technology

基　　金：陕西省自然科学基础研究计划一般项目(青年)(2023-JC-QN-0116);陕西省重点研发计划(2023-YBNY-068);省部共建生物催化与酶工程国家重点实验室2022年度开放课题(SKLBEE20220016)。

摘　　要：生物污染已成为一个影响全球的当代社会问题,它波及医疗、食品加工、环境保护等多个领域,并引发了严重的健康和环境安全隐患。近年来,蛋白质基涂层作为一种新兴的防污技术,受到了广泛关注。综述了生物污染在食品、生物医学和工业生产中的危害,并分析了蛋白质表面涂层策略在防止生物污染中的优势。具体包括,利用蛋白质特异性结构和功能团,通过自组装或化学修饰形成抗生物污染涂层;蛋白质与小分子复合,以增强抗菌能力;蛋白质与高分子材料结合,形成具有优异力学强度和化学稳定性的涂层。最后总结了蛋白质基防污涂层的优势及其未来面临的挑战。Biofouling has emerged as a significant global issue which affects various sectors including medical care,food processing,environmental management,and everyday life.The consequences of biofouling are multifaceted and far-reaching,posing considerable risks to both human health and environmental sustainability.This paper seeks to address these critical concerns by providing a comprehensive overview of the diverse hazards posed by biofouling,particularly in the contexts of food production,biomedical applications,and industrial processes.Biofouling can lead to equipment malfunction,reduced operational efficiency,contamination,and increased healthcare-associated infections,making it a priority for industries to develop effective mitigation strategies.The biofouling process involves the adhesion and accumulation of biological materials,such as proteins,bacteria,and biofilms on surfaces exposed to water or other liquids.Once established,these biofilms will create a breeding ground for pathogens and other microorganisms,exacerbating contamination risks and leading to costly and time-consuming maintenance.This paper explores the underlying mechanisms of biofouling formation,which involves complex biological interactions at the molecular level,including initial protein adsorption followed by bacterial attachment and biofilm development.These mechanisms highlight the need for advanced technologies to counteract biofouling before it becomes problematic.The surface coating technology has become one of the most promising approaches to mitigating biofouling.By creating protective barriers between the surface and the biological environment,these coatings can prevent the adhesion and growth of biological pollutants.Among the various types of antifouling coatings,protein-based coatings have gained significant attention due to their unique properties.Proteins offer a versatile platform for the development of antifouling materials because of their structural diversity and the presence of various functional groups such as hydroxyl,ca

关 键 词：生物污染 蛋白质 防污 涂层 表面改性 

分 类 号：TB332[一般工业技术—材料科学与工程]