基于数据挖掘探讨古代肝积的中药处方配伍规律及应用特点  

Exploring the traditional Chinese medicine medication laws and characteristic of ancient Ganji based on data mining

作　　者：葛书怡 李斯曼 陶孟瑶[2] 旷吉琳 阎博华[2] GE Shuyi;LI Siman;TAO Mengyao;KUANG Jilin;Yan Bohua(School of Clinical Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 610072,Sichuan;The Affliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan)

机构地区：[1]成都中医药大学临床医学院,四川成都610072 [2]成都中医药大学附属医院,四川成都610075

出　　处：《中药与临床》2024年第6期54-58,共5页Pharmacy and Clinics of Chinese Materia Medica

基　　金：成都中医药大学附属医院院基金(238YTS1905);成都中医药大学附属医院百人计划(21-Y21,20-Q03);成都中医药大学“杏林学者”项目(QNXZ2020003)。

摘　　要：目的:通过数据挖掘技术整理并总结古代治疗肝积的中药用药规律及临床应用特点。方法:以《中华医典》(第5版)收录的1156部古籍为古代文献检索来源,对肝积的方剂名称、中药组成、剂型及煎服法等进行统计整理并建立数据库。结果:纳入符合的处方40首,共涉及中药124味,总频数440次。高频中药为柴胡、黄连、木香、干姜、大黄等,中药功效归类前3分别为补益药、温里药、活血化瘀药。关联规则及复杂网络分析得出柴胡、黄连、干姜、厚朴、人参之间存在的链接较强。核心药对为柴胡-黄连、人参-干姜、厚朴-干姜、柴胡-干姜、黄连-干姜。聚类分析得出5个核心药物组合。药物剂型以丸剂为主,煎服法以酒配服为主,丸剂制法以炼蜜为丸和醋糊为丸为主。结论:古代肝积治疗用药以补气理气,疏肝消积为主,攻补并用,且多用丸剂以和峻药而不伤正。Objective: By using data mining techniques to organize and summarize the traditional Chinese medicine medication patterns and clinical application characteristics for the treatment of Ganji in ancient times. Method: Using 1156 ancient books included in the 5th edition of the Chinese Medical Code as the source of ancient literature search, this study conducted a statistical analysis and established a database on the names of formulas, traditional Chinese medicine compositions,dosage forms, and decoction methods of Ganji. Results: 40 prescriptions were included, involving a total of 124 traditional Chinese medicines, with a total frequency of 440 times. High frequency traditional Chinese medicine includes Bupleuri Radix(Chaihu), Coptidis Rhizoma(Huanglian), Aucklandiae Radix(Muxiang), Zingiberis Rhizoma(Ganjiang), Rhei Radix et Rhizoma(Dahuang), etc. The top three Chinese medicine efficacy categories were tonifying medicine, warming medicine, and promoting blood circulation and removing blood stasis medicine. Association rules and complex network analysis indicated that there were strong links between Chaihu, Huanglian, Ganjiang, Magnoliae Officinalis Cortex(Houpo), and Ginseng Radix et Rhizoma(Renshen). The core drug pairs were Chaihu-Huanglian, Renshen-Ganjiang, Houpo-Ganjiang, Chaihu-Ganjiang, and Huanglian-Ganjiang. Cluster analysis identified 5 core drug combinations. The drug dosage form was mainly pills. The decoction method was mainly composed of alcohol, and the pill preparation method was mainly composed of honey refining pills and vinegar paste pills. Conclusion: In ancient times, the treatment of liver accumulation mainly focus on tonifying qi, regulating qi, soothing the liver, and eliminating accumulation. It is used in combination with attacking and tonifying, and often used pills to mix with strong medicines without harming the body.

关 键 词：肝积 文献研究 肥气 用药规律 数据挖掘 

分 类 号：R256[医药卫生—中医内科学]