血清受体相互作用蛋白激酶浓度与儿童支气管哮喘急性发作的相关性  

Correlation of serum levels of receptor interacting protein kinase with acute attack of bronchial asthma in children

作　　者：杨佳 李文斌 Yang Jia;Li Wenbin(Third Department of Respiratory Medicine,the Affiliated Xuzhou Children's Hospital of Xuzhou Medical University,Xuzhou 221006,China)

机构地区：[1]徐州医科大学附属徐州儿童医院呼吸内三科,徐州221006

出　　处：《国际呼吸杂志》2024年第11期1306-1311,共6页International Journal of Respiration

基　　金：徐州市重点研发计划项目(KC22200)。

摘　　要：目的探讨血清受体相互作用蛋白激酶(RIPK)浓度与儿童支气管哮喘(哮喘)急性发作的相关性。方法本研究为横断面研究, 采用非随机抽样的方法选取2021年2月至2024年2月在徐州医科大学附属徐州儿童医院住院的122例哮喘急性发作期患儿作为哮喘组。根据哮喘急性发作病情严重程度将哮喘组患儿分为轻度哮喘组(31例)、中度哮喘组(53例)和重度哮喘组(38例)。另选取同期接受体检的32名健康儿童作为健康对照组。收集哮喘患儿和健康儿童的临床资料, 包括性别、年龄、实验室检查指标[入院/入组时、治疗/入组72 h后检测的血清RIPK1、RIPK3和混合谱系激酶结构域样蛋白质(MLKL)浓度, ΔRIPK3(入院/入组时检测的血清RIPK3浓度-治疗/入组72 h后检测的血清RIPK3浓度)]和肺功能指标[第1秒用力呼气容积(FEV_(1))占预计值百分比(%pred)、用力肺活量(FVC)%pred、呼气流量峰值(PEF)%pred]。记录哮喘患儿的哮喘急性发作严重程度、哮喘急性发作持续天数和肺功能完全恢复天数。采用Pearson相关分析评估哮喘患儿入院时的血清RIPK3浓度与肺功能指标、哮喘患儿ΔRIPK3与哮喘急性发作持续天数和肺功能完全恢复天数的相关性;采用Spearman秩相关分析评估哮喘患儿入院时的血清RIPK3浓度、ΔRIPK3与哮喘急性发作严重程度的相关性。结果健康对照组男18名, 女14名, 年龄(8.32±1.56)岁;轻度哮喘组男16例, 女15例, 年龄(7.99±1.09)岁;中度哮喘组男30例, 女23例, 年龄(8.02±1.21)岁;重度哮喘组男21例, 女17例, 年龄(7.69±1.29)岁;4组儿童性别和年龄比较差异均无统计学意义(均P>0.05)。轻度哮喘组、中度哮喘组和重度哮喘组患儿血清RIPK1、RIPK3、MLKL浓度和ΔRIPK3均高于健康对照组儿童, 差异均有统计学意义(均P<0.05)。哮喘组患儿入院时的血清RIPK3浓度高于健康对照组儿童入组时的血清RIPK3浓度, 而FEV_(1)%pred、FVC%pred和PEF%prObjective:To explore the correlation between serum receptor interaction protein kinase(RIPK)concentration and the acute attack of bronchial asthma(asthma)in children.Methods:This was a cross-sectional study.Using non-random sampling,122 children with acute attack of asthma hospitalized in the Affiliated Xuzhou Children′s Hospital of Xuzhou Medical University from February 2021 to February 2024 were selected as asthma group,and divided into mild asthma group(31 cases),moderate asthma group(53 cases)and severe asthma group(38 cases)according to the severity.In addition,32 healthy children who underwent physical examination in the same period were selected as the health control group.Clinical data of children with asthma and healthy children,including sex,age,laboratory examination indicators on admission/recruitment and 72 h of admission/recruitment(serum RIPK1,RIPK3 and mixed lineage kinase domain-like protein[MLKL],andΔRIPK3[difference between at baseline and 72 h in the serum level])and lung function indicators(forced expiratory volume in one second[FEV_(1)]as a percentage of the predicted value[%pred],forced vital capacity[FVC]%pred,peak expiratory flow[PEF]%pred).The severity of acute asthma attacks,the number of days of acute asthma attacks and the number of days of complete recovery of lung function in children with asthma were recorded.Pearson correlation analysis was used to evaluate the correlation of serum RIPK3 with lung function indicators of children with asthma on admission,ΔRIPK3 in asthma children with the number of days of acute attack asthma and the number of days of complete recovery of pulmonary function.Spearman rank correlation analysis was used to evaluate the correlation of serum RIPK3 andΔRIPK3 with the severity of acute asthma on admission.Results:There were 18 male cases and 14 female cases in the healthy control group,with a mean age of(8.32±1.56)years.There were 16 male cases and 15 female cases in the mild asthma group,with a mean age of(7.99±1.09)years;and 30 male cases and 23

关 键 词：哮喘 儿童 受体相互作用蛋白激酶 急性发作 

分 类 号：R725.6[医药卫生—儿科]