m6A甲基化修饰在肺动脉高压中的研究进展  

Progress of m6A methylation modification in pulmonary hypertension

作　　者：杨晨 孙书芳 胡婷 韩伟[3] 李庆海 于新娟[3] 郝万明[3] Yang Chen;Sun Shufang;Hu Ting;Han Wei;Li Qinghai;Yu Xinjuan;Hao Wangming(School of Clinical Medicine,Shandong Second Medical University,Weifang261053,China;QingdaoCentral Blood Station Business Departmen,tQ,ingdao 266071,China;Department of Respiratory and Critical Medicine,Qingdao Hospital,University of Health and Rehabilitation Sciences(Qingdao Municipal Hospital),Qingdao 266071,China)

机构地区：[1]山东第二医科大学临床医学院,潍坊261053 [2]青岛市中心血站业务科,青岛266071 [3]康复大学青岛医院(青岛市市立医院)呼吸与危重症医学科,青岛266071

出　　处：《国际呼吸杂志》2024年第11期1354-1359,共6页International Journal of Respiration

基　　金：国家自然科学基金(81900048);青岛市市南区科技计划项目(2022-4-002-YY)。

摘　　要：N6-甲基腺苷(m6A)修饰是真核细胞中最普遍、最丰富和最保守的RNA修饰方式,受到m6A甲基化酶、去甲基化酶和结合蛋白这3种酶的动态调控,涉及RNA加工的各个方面,参与机体多种病理生理过程。肺动脉高压(PH)是一种以不可逆的肺血管重塑为特征的血管病变,预后差,目前针对其治疗方法仍有限。越来越多研究表明m6A修饰在心血管疾病中具有重要作用,本文总结了不同m6A修饰调节因子在PH中的作用及其机制,以便了解PH的发病机制,为后续药物开发提供新的方向与见解。N6-methyladenosine(m6A)methylation is the most prevalent,abundant,and conserved RNA modification in eukaryotic cells.It is dynamically regulated by three enzymes:m6A methylases,demethylases,and binding proteins.m6A modification participates in various aspects of RNA processing and plays a crucial role in numerous pathophysiological processes in the organism.Pulmonary hypertension(PH)is a vascular disorder characterized by irreversible pulmonary vascular remodeling(PVR),showing a poor prognosis and lacking effective treatments.Increasing evidences suggest the significant role of m6A modification in cardiovascular diseases.Therefore,this paper summarized the functions of various m6A modification regulators of PH and their underlying mechanisms,aiming to enhance our understanding of the pathogenesis of PH and provide novel directions and insights for future drug development.

关 键 词：高血压 肺性 表观遗传 m6A修饰 RNA修饰 

分 类 号：R544.1[医药卫生—心血管疾病]