鲁西南地区常染色体显性多囊肾病患者疾病进展临床指标的相关性分析  

Correlation analysis of clinical indicators of disease progression in patients with autosomal dominant polycystic kidney disease in southwest Shandong province

作　　者：董辉辉 徐璐[2] 李新建[3] 杜海涛 Dong Huihui;Xu Lu;Li Xinjian;Du Haitao(Nephrology Department,Yanzhou People’s Hospital,Jining 272000,China;不详)

机构地区：[1]山东省济宁市兖州区人民医院肾内科,272000 [2]济宁医学院附属医院血液净化科 [3]济宁医学院附属医院肾内科

出　　处：《临床内科杂志》2024年第11期743-747,共5页Journal of Clinical Internal Medicine

基　　金：山东省医药卫生科技发展计划项目(2014WS0199)。

摘　　要：目的统计鲁西南地区常染色体显性多囊肾病(ADPKD)患者的临床资料,分析与ADPKD进展相关的临床指标。方法纳入ADPKD患者200例,通过各临床指标与估算的肾小球滤过率(eGFR)的检验,寻找与ADPKD进展相关的指标,分别计算eGFR、lg(eGFR)与各指标的样本相关系数,比较二者在线性相关分析中的优劣。采用共线性筛查进一步筛选指标,通过样本偏相关系数、复相关系数的计算,研究相关指标间的相互影响。建立多元线性回归分析模型,找出评估ADPKD进展的优选参考指标。结果在鲁西南地区,BMI肥胖和超重的ADPKD患者比BMI正常和消瘦的患者平均年轻3.3~5.2岁。通过各临床指标与eGFR的χ^(2)检验,得到16种与ADPKD进展相关的临床指标,发现用lg(eGFR)进行线性相关性分析比eGFR更合适。胱抑素C(CysC)、β_(2)-微球蛋白(β_(2)-MG)、血尿素氮(BUN)、血磷(P)、血尿酸(SUA)与ADPKD进展均呈负相关,Hb、RBC计数、红细胞比容(HCT)、碳酸氢盐(Bicarb)、间接胆红素(IBiL)、淋巴细胞计数(LYMC)、尿比重(USG)、总胆红素(TBiL)、PLT压积(PCT)、PLT计数及WBC计数与ADPKD进展均呈正相关(P<0.05)。ADPKD进展与相关指标的关系是综合性的,用CysC、BUN和Hb构建lg(eGFR)的线性回归模型是有意义的。结论鲁西南地区超重及肥胖ADPKD患者总体上更年轻,患者肥胖问题值得关注。与ADPKD进展相关的指标较多且相互影响,其中CysC、BUN和Hb是较好的参考指标。Objective The clinical data of patients with autosomal dominant polycystic kidney disease(ADPKD)in southwest Shandong were analyzed,and the clinical indicators related to the progression of ADPKD were analyzed.Methods A total of 200 ADPKD patients were included.By examining each clinical indicator and the estimated glomerular filtration rate(eGFR),the indicators related to the progression of ADPKD were sought.The sample correlation coefficients of eGFR,lg(eGFR)and each index were calculated respectively,and their advantages and disadvantages in linear correlation analysis were compared.Collinear screening was used to further screen indicators,and the mutual influence of relevant indicators was studied through the calculation of sample partial correlation coefficient and complex correlation coefficient.Multiple linear regression analysis model was established to find out the optimal reference index for evaluating the progress of ADPKD.Results In southwest Shandong Province,ADPKD patients with obese and overweight BMI were on average 3.3 to 5.2 years younger than patients with normal and thin BMI.Through theχ^(2) test of each clinical index and eGFR,16 clinical indicators related to the progression of ADPKD were obtained.It was found that lg(eGFR)was more suitable for linear correlation analysis than eGFR.Cystatin C(CysC),β_(2)-microglobulin(β_(2)-MG),blood urea nitrogen(BUN),blood phosphorus(P)and blood uric acid(SUA)were negatively correlated with the progression of ADPKD,whileHb,RBC count,hematocrit value(HCT),bicarbonate(Bicarb),indirect bilirubin(IBiL),lymphocyte count(LYMC),urinary specific gravity(USG),total bilirubin(TBiL),PLT volume(PCT),PLT count and WBC count were positively correlated with the progression of ADPKD(P<0.05).The relationship between ADPKD progress and related indicators was comprehensive,and the linear regression model of lg(eGFR)constructed with CysC,BUN and Hb was meaningful.Conclusion In southwestern Shandong Province,the overweight and obese patients with ADPKD are generally younger

关 键 词：鲁西南地区 常染色体显性多囊肾病 疾病进展 临床指标 相关性 

分 类 号：R596[医药卫生—内科学]