2013—2022年长沙市丙型肝炎流行特征和趋势分析  

Epidemiological characteristics and trend analysis of hepatitis C in Changsha from 2013 to 2022

作　　者：赵锦[1] 周银柱[1] 陈水连[1] 邱劲松 查文婷[2] ZHAO Jin;ZHOU Yinzhu;CHEN Shuilian;QIU Jinsong;ZHA Wenting(Center for Disease Control and Prevention of Changsha City,Changsha,Hunan 410000,China;不详)

机构地区：[1]长沙市疾病预防控制中心,湖南长沙410000 [2]湖南师范大学医学院分子流行病学湖南省重点实验室,湖南长沙410000

出　　处：《中国病毒病杂志》2024年第5期451-456,共6页Chinese Journal of Viral Diseases

基　　金：湖南省自然科学基金项目(2024JJ9547)。

摘　　要：目的 掌握长沙市丙型肝炎流行特征和趋势,并分析新型冠状病毒(简称新冠病毒)流行及防控背景下长沙市丙型肝炎流行情况,为丙型肝炎防控提供科学依据。方法 收集2013—2022年长沙市现住人口的丙型肝炎病例信息,分新型冠状病毒感染流行前(2013—2019年)及流行期间(2020—2022年)两个时间段对长沙市丙型肝炎病例的时间、地区、人群分布特征进行统计分析,趋势分析采用Joinpoint回归分析,率的组间比较采用χ^(2)检验。结果 2013—2022年长沙市累计报告丙型肝炎12 249例,年均报告发病率15.25/10万。2013—2019年报告发病率由17.42/10万降至16.89/10万,报告发病率趋于平稳(APC=0.17,P=0.95),2020—2022年报告发病率由13.38/10万降至10.82/10万,报告发病率呈下降趋势(APC=-12.73,P=0.03),报告发病率年平均下降12.73%。丙型肝炎流行无明显季节性,高报告发病率区主要集中于中心城区和浏阳市;2013—2019年与2020—2022年,男、女性报告发病率差异均有统计学意义(χ^(2)=66.88,P<0.001;χ^(2)=32.35,P<0.001),男性报告发病率高于女性;报告病例主要集中在35~<65岁年龄组。2013—2019年该年龄组人群男、女性累计病例数构成比分别为72.24%(3492/4834)、 61.22%(2 357/3 850),而2020—2022年则为74.85%(1 494/1 996)、64.63%(1 014/1 569);2013—2019年与2020—2022年排名前三的职业均为农民、家务及待业、离退人员。2013—2019年与2020—2022年农民、离退人员职业构成比变化差异有统计学意义(χ^(2)=7.73,P=0.005;χ^(2)=10.47,P=0.001);家务及待业职业构成比变化差异无统计学意义(χ^(2)=2.99,P=0.08)。2013—2019年丙型肝炎流行的时间、地区和人群分布与2020—2022年比较差异无统计学意义。结论 相较于新冠病毒感染流行前,新冠病毒感染流行期间长沙市丙型肝炎报告发病率明显下降。新冠病毒感染流行前和流行期间,长沙市丙型肝炎病例的年龄、性别、�Objective To analyze the epidemic characteristics and trends of hepatitis C in Changsha city and to analyze the situation under the context of the COVID-19 pandemic,and to provide a scientific basis for the prevention and control of hepatitis C.Methods Data on hepatitis C cases among the resident population of Changsha city from 2013 to 2022 were collected.Statistical analyses were conducted to assess the temporal,regional,and demographic distribution of cases before(2013 – 2019) and during(2020 – 2022) the COVID-19 pandemic.The trend analysis was performed by joinpoint regression analysis,and the comparison of rates between groups was performed by χ^(2) test.Results From 2013 to 2022,a total of 12 249 cases of hepatitis C were reported in Changsha city,with an average annual incidence of 15.25/100 000.From 2013 to 2019,the reported incidence rate decreased from 17.42/100 000 to 16.89/100 000,and the reported incidence rate tended to be stable(APC=0.17,P=0.95).From 2020 to 2022,the reported incidence rate decreased from 13.38/100 000 to 10.82/100 000,and the reported incidence rate showed a downward trend(APC=-12.73,P=0.03) and the annual average reported incidence rate decreased by 12.73 %.There was no obvious seasonality in the prevalence of hepatitis C,and the highincidence areas were mainly concentrated in the central urban area and Liuyang city.There were statistically significant differences in the reported incidence rates for different genders between 2013-2019 and 2020-2022 (χ^(2)=66.88,P<0.001;χ^(2)=32.35,P<0.001),with males showing higher rates.The reported cases were mainly concentrated in the 35-<65 age group.From 2013 to 2019,the proportion of the cumulative number of cases for male and female in this age group was 72.24%(3 492/4 834) and 61.22%(2 357/3 850),respectively,compared with 74.85%(1 494/1 996) and 64.63%(1 014/1 569) in 2020-2022.The top three occupations in 2013-2019 and 2020-2022were farmers,housemakers and unemployed,and retirees.There was a statistically significant difference i

关 键 词：新型冠状病毒感染 丙型肝炎 流行特征 Joinpoint回归分析 

分 类 号：R512.6[医药卫生—内科学]