基于喉高速摄影分析咽喉反流患者的声带运动及发声启动行为  

Analysis of vocal fold movement and voice onset behavior in patients with laryngopharyngeal reflux based on high speed laryngeal high-speed videoendoscopy

作　　者：徐新林[1,2] 黄雪琼 李湘平 庄佩耘[1] XU Xinlin;HUANG Xueqiong;LI Xiangping;ZHUANG Peiyun(Department of Voice,Zhongshan Hospital of Xiamen University,Department of Otolaryngology in School of Medicine,Xiamen University,Xiamen,361004,China;Department of Otolaryngology, Southern Medical University Nanfang Hospital)

机构地区：[1]厦门大学附属中山医院嗓音科,福建厦门361004 [2]南方医科大学南方医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2024年第11期1031-1037,共7页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金(No:82000970);福建省自然科学基金(No:2021J011331)。

摘　　要：目的:咽喉反流(laryngopharyngeal reflux,LPR)患者咽喉部黏膜存在慢性炎症,这些炎症导致咽喉部处于高反应状态,可能会使得声带运动出现过快的表现。本文通过分析LPR患者的喉高速摄影录像,探讨LPR患者的声带运动及发声启动特点。方法:入选咽喉反流患者40例为LPR组,LPR诊断标准:反流症状指数(RSI)及反流体征评分(RFS)阳性确定疑似LPR;进行客观的口咽部Dx pH监测,Ryan指数阳性提示有反流。根据年龄及性别匹配入选健康志愿者40例为正常对照组。对受试者进行喉高速摄影录像,分析声带运动及振动参数:声带内收时间、声带外展时间、声带振动启动模式(发声启动时间及起音方式)及声带振动周期的开放商。采用SPSS 25.0进行统计学分析。结果:LPR组声带内收时间(平均225.81 ms)小于对照组(平均277.01 ms)(P<0.05)。LPR组声带两侧的内收时间差与对照组间差异无统计学意义(P>0.05)。LPR组的声带振动启动时间大于对照组(P<0.05)。喉高速摄影下显示LPR组硬起音患者数(17例)多于对照组(8例)(P<0.05)。LPR组声带振动的开放商与对照组的差异无统计学意义(P>0.05)。LPR组的声带外展时间(平均372.92 ms)与对照组(平均426.98 ms)间差异无统计学意义(P>0.05)。LPR组声带两侧外展时间差大于对照组(P<0.05)。结论:LPR患者声带运动速度较快,且更容易出现硬起音发声模式,导致嗓音功能障碍。Objective:Patients with Laryngopharyngeal Reflux(LPR) have chronic inflammation of the laryngeal mucosa leading to a high response state in the larynx,which may make the vocal fold movement too fast.This paper discusses the characteristics of vocal fold movement and voice onset by analyzing laryngeal high-speed videoendoscopy in patients with LPR.Methods:Forty patients with LPR were enrolled as LPR group.The diagnostic criteria of LPR included positive reflux symptom index(RSI) and reflux syndrome score(RFS) to identify suspected LPR,objective oropharyngeal DX pH monitoring was carried out,and positive Ryan index indicated reflux.According to age and sex matching,40 healthy volunteers were selected as the normal group.Laryngeal high-speed videoendoscopy,and the vocal fold motion and vibration parameters,including vocal fold adduction time,vocal fold abduction time,vocal fold vibration onset mode(vocal onset time and mode) and the opening quotient of vocal fold vibration cycle.Statistical analysis was performed using SPSS 25.0.Results:The time of vocal fold adduction in LPR group(mean 225.81ms) was less than that in normal group(mean 277.01 ms),and the difference was statistically significant(P<0.05).There was no significant difference in adduction time between LPR group and normal group(P>0.05).The vocal onset time in LPR group was significantly longer than that in normal group(P<0.05).High speed video endoscope showed that there were 17 patients with hard onset in LPR group and 8 patients with hard onset in normal group,the difference was statistically significant(P<0.05).There was no significant difference in the open quotient of vocal fold vibration between LPR group and normal group(P>0.05).The vocal fold abduction time in LPR group(mean 372.92 ms) was less than that in normal group(mean 426.98ms),but the difference was not statistically significant(P>0.05).The time difference of bilateral abduction of vocal fold in LPR group was significantly higher than that in normal group(P<0.05).Conclusion:The larynx of

关 键 词：咽喉反流性疾病 喉高速摄影 声带运动 发声启动时间 发声振动 

分 类 号：R767.4[医药卫生—耳鼻咽喉科]