阿托伐他汀治疗冠心病心律失常的效果及其对心功能的影响  

The Effect of Atorvastatin on Arrhythmia in Coronary Heart Disease and Its Impact on Cardiac Function

作　　者：秦未来 廖炜琦 潘兴寿[2] QIN Weilai;LIAO Weiqi;PAN Xingshou(Graduate School,Youjiang Medical University for Nationalities,Baise Guangxi 533000,China;Department of Cardiology,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise Guangxi 533000,China)

机构地区：[1]右江民族医学院研究生学院,广西百色533000 [2]右江民族医学院附属医院心血管内科,广西百色533000

出　　处：《中国卫生标准管理》2024年第21期133-137,共5页China Health Standard Management

基　　金：2024年广西硕士研究生创新项目(YCSW2024540)。

摘　　要：目的探究阿托伐他汀治疗冠心病心律失常的效果及其对心功能的影响。方法将右江民族医学院附属医院2022年10月—2024年4月收治的80例冠心病心律失常患者作为研究对象,基于不同治疗方法,分为对照组与观察组,各40例。对照组给予琥珀酸美托洛尔缓释片治疗,观察组给予琥珀酸美托洛尔缓释片联合阿托伐他汀治疗。比较2组患者治疗效果、心功能改善及不良反应发生等情况。结果观察组治疗总有效率为97.50%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后观察组血液流变学指标全血高切黏度、全血低切黏度、血浆黏度、红细胞聚集指数分别是(4.01±0.54)mPa·s、(8.18±1.04)mPa·s、(1.07±0.35)mPa·s、(2.14±0.21),均明显低于对照组的(4.76±0.87)mPa·s、(9.63±1.26)mPa·s、(1.63±0.41)mPa·s、(2.72±0.32),差异有统计学意义(P<0.05)。治疗后观察组心功能指标左心室射血分数为(60.22±5.14)%,明显高于对照组的(51.17±4.85)%,观察组左心室收缩末期内径、左心室舒张末期内径分别为(40.03±4.04)mm、(46.52±4.63)mm,均明显低于对照组的(44.76±4.39)mm、(52.35±5.84)mm,差异有统计学意义(P<0.05)。治疗后观察组白细胞介素-6、C反应蛋白、肿瘤坏死因子-α分别为(4.41±1.13)pg/mL、(5.05±1.12)mg/L、(6.11±2.42)ng/L,均明显低于对照组的(6.05±1.08)pg/mL、(7.96±1.51)mg/L、(8.82±2.71)ng/L,差异有统计学意义(P<0.05)。观察组不良反应发生率为5.00%,低于对照组的25.00%,差异有统计学意义(P<0.05)。结论在冠心病心律失常治疗中,阿托伐他汀治疗效果显著,可提高治疗有效率,改善心功能水平,且不良反应低,用药安全性高。Objective To explore the efficacy of atorvastatin in treating coronary heart disease arrhythmias and its effect on improving cardiac function.Methods A total of 80 patients with coronary heart disease and arrhythmia admitted to Affiliated Hospital of Youjiang Medical University for Nationalities from October 2022 to April 2024 were selected as the study subjects.Based on different treatment methods,they were divided into a control group and an observation group,with 40 cases in each group.The control group was treated with metoprolol succinate sustained-release tablets,while the observation group was treated with metoprolol succinate sustained-release tablets combined with atorvastatin.The treatment effects,cardiac function improvement,and incidence of adverse reactions were compared and observed between the two groups.Results The effective treatment rate of the observation group was 97.50%,which was higher than the control group's 80.00%,the difference was statistically significant(P<0.05).After treatment,the hemorheological indicators of the observation group,including whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,and red blood cell aggregation index,were(4.01±0.54)mPa·s,(8.18±1.04)mPa·s,(1.07±0.35)mPa·s,and(2.14±0.21),respectively,which were significantly lower than those of the control group(4.76±0.87)mPa·s,(9.63±1.26)mPa·s,(1.63±0.41)mPa·s,and(2.72±0.32),with statistical significance(P<0.05).After treatment,the left ventricular ejection fraction in the observation group was(60.22±5.14)%,which was significantly higher than that in the control group(51.17±4.85)%,the left ventricular end systolic diameter and left ventricular end diastolic diameter in the observation group were(40.03±4.04)mm and(46.52±4.63)mm,respectively,which were significantly lower than those in the control group(44.76±4.39)mm and(52.35±5.84)mm,and the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6,C-reactive protein,and tumor necrosis fa

关 键 词：冠心病 心律失常 阿托伐他汀 疗效 心功能 不良反应 

分 类 号：R541[医药卫生—心血管疾病]