麝香通心滴丸治疗微血管性心绞痛的疗效及临床安全性  

Efficacy of Shexiang Tongxin Dripping Pills in the Treatment of Microvascular Angina Pectoris and Its Clinical Safety

作　　者：郑文辉[1] 吴瑞华[1] ZHENG Wenhui;WU Ruihua(Department of Cardiovascular,Zhangzhou Traditional Chinese Medicial Hospital,Zhangzhou Fujian 363000,China)

机构地区：[1]漳州市中医院心血管科,福建漳州363000

出　　处：《中国卫生标准管理》2024年第21期160-163,168,共5页China Health Standard Management

基　　金：福建省2022年省级临床重点专科建设项目(闽卫医政函〔2022〕884号)。

摘　　要：目的探讨麝香通心滴丸治疗微血管性心绞痛(microvascular angina,MVA)的效果及用药安全性。方法选取2021年12月—2022年12月漳州市中医院收治的MVA患者100例,随机分为麝香组(n=52)和西医组(n=48)。西医组采用β受体阻滞剂或伊伐布雷定治疗,麝香组则在西医组的基础上联用麝香通心滴丸。对比2组左室射血分数、平板运动持续时间等指标。结果治疗12周后,麝香组左室射血分数为(68.28±5.13)%,显著高于西医组的(57.29±4.21)%,差异有统计学意义(P<0.05)。麝香组平板运动持续时间为(534.13±95.23)s,显著高于西医组的(471.25±85.13)s,差异有统计学意义(P<0.05)。麝香组心绞痛持续时间为(2.27±0.13)min,短于西医组的(4.24±0.32)min,差异有统计学意义(P<0.05)。心绞痛发作频率为(3.53±0.25)次,显著少于西医组的(6.43±0.15)次,差异有统计学意义(P<0.05)。麝香组LAD、LCX、RCA血流帧数分别为(32.19±1.29)帧、(28.27±4.20)帧和(27.24±2.15)帧,均少于西医组的(38.35±1.24)帧、(34.11±3.18)帧和(33.24±2.29)帧,差异有统计学意义(P<0.05)。2组不良反应均较轻微,对症治疗后症状消失。结论麝香通心滴丸联合西药治疗MVA可有效改善心肌缺血程度,提高冠脉微血管血流量,临床疗效显著,安全性高。Objective To investigate the efficacy and clinical safety of Shexiang Tongxin dripping pills in the treatment of microvascular angina pectoris.Methods From December 2021 to December 2022,a total of 100 patients with microvascular angina pectoris admitted to Zhangzhou Traditional Chinese Medicial Hospital were randomly divided into musk group(n=52)and western medicine group(n=48).The western medicine group was treated withβ-blocker or ivabradine,and the Shexiang group was treated with Shexiang Tongxin dripping pills on the basis of the western medicine group.Left ventricular ejection fraction and treadmill exercise duration were compared between the two groups.Results After 12 weeks of treatment,the left ventricular ejection fraction(LVEF)of the musk group was(68.28±5.13)%,which was significantly higher than that of the western medicine group(57.29±4.21)%,and the differences were statistically significant(P<0.05).The duration of treadmill exercise in the musk group was(534.13±95.23)s,which was significantly higher than that in the western medicine group(471.25±85.13)s,and the differences were statistically significant(P<0.05).The duration of angina pectoris in the musk group was(2.27±0.10)min,which was significantly shorter than(4.24±0.30)min in the western medicine group,and the differences were statistically significant(P<0.05).The frequency of angina pectoris attack was(3.55±0.25)times,which was significantly lower than that(6.45±0.15)times in the western medicine group,and the differences were statistically significant(P<0.05).The number of LAD,LCX,and RCA blood flow frames in the musk group were(32.19±1.29)frames,(28.27±4.20)frames,and(27.24±2.15)frames,respectively,which were lower than those inthe Western medicine group(38.35±1.24)frames,(34.11±3.18)frames,and(33.24±2.29)frames,and the difference was statistically significant(P<0.05).The adverse reactions in both groups were mild and disappeared after symptomatic treatment.Conclusion The combination of Shexiang Tongxin dripping pills and west

关 键 词：麝香通心滴丸 微血管性心绞痛 伊伐布雷定 Β受体阻滞剂 校正冠脉血流TIMI帧数 左室射血分数 

分 类 号：R541[医药卫生—心血管疾病]